Table 3.

Percentage of CD45+ Cells Detected in the BM of NOD/SCID Mice Injected With Unsorted AML Peripheral Blood Cells

Patient No. 5 × 106No. of Cells Injected3-150No. of Positive Colonies by FISH
1065 × 105105≤5 × 104
2  92  57 ± 3   2  0  0  7/8  
3  21  15  ND ND  ND  6/6  
 30 ± 10   42  5  0  4/123-151 
5  0  ND  ND  ND  ND  
8  95 97 ± 0.6  92  66  26  26/26  
9  0.2  ND  ND  ND  10/10  
10  0.1  0  0  0  ND  
12   ND 0.2  0  0  ND  
13   0.14  0  0  ND  
15   30 ± 6    9  0  ND  
17   13  11  8  ND  
18   0  0  ND ND  ND 
Patient No. 5 × 106No. of Cells Injected3-150No. of Positive Colonies by FISH
1065 × 105105≤5 × 104
2  92  57 ± 3   2  0  0  7/8  
3  21  15  ND ND  ND  6/6  
 30 ± 10   42  5  0  4/123-151 
5  0  ND  ND  ND  ND  
8  95 97 ± 0.6  92  66  26  26/26  
9  0.2  ND  ND  ND  10/10  
10  0.1  0  0  0  ND  
12   ND 0.2  0  0  ND  
13   0.14  0  0  ND  
15   30 ± 6    9  0  ND  
17   13  11  8  ND  
18   0  0  ND ND  ND 

Abbreviation: ND, not determined.

F3-150

In four of the cases shown, the values represent the mean ± SEM % of CD45+ cells in femoral marrow of at least 3 NOD/SCID mice. All other values represent the result from a single mouse injected with the number of cells indicated.

F3-151

Of the remaining 8 colonies, 5 were undetermined and 3 were negative.

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