Table 2.

Morphometric Studies of Thrombin-Induced ICGF

Time After 5 Min Treatment With 0.1 U/mL Thrombin in HAH
PT*5 sec 2 min 5 min 10 min 20 min 40 min
Total area  7,638  7,545  7,584 7,638  7,578  7,612  7,621  
Cell area  7,286 3,647  3,248  2,669  2,487  2,342  2,291  
Gaps† 352  3,898  4,336  4,969  5,091  5,270  5,330 
% Gaps‡ 4.6  51.7  57.2  65.1  67.2  69.2 69.9  
Fold gap inc1-153 None  10  11  13 14  14  14  
 
 Time After 5 min Treatment With HAH 
 PT*      40 min  
Total area  7,603      7,603  
Cell area  7,514      7,531  
Gaps† 89      72  
% Gaps‡ 1.2      0.9  
Fold gap inc1-153 None      0 
Time After 5 Min Treatment With 0.1 U/mL Thrombin in HAH
PT*5 sec 2 min 5 min 10 min 20 min 40 min
Total area  7,638  7,545  7,584 7,638  7,578  7,612  7,621  
Cell area  7,286 3,647  3,248  2,669  2,487  2,342  2,291  
Gaps† 352  3,898  4,336  4,969  5,091  5,270  5,330 
% Gaps‡ 4.6  51.7  57.2  65.1  67.2  69.2 69.9  
Fold gap inc1-153 None  10  11  13 14  14  14  
 
 Time After 5 min Treatment With HAH 
 PT*      40 min  
Total area  7,603      7,603  
Cell area  7,514      7,531  
Gaps† 89      72  
% Gaps‡ 1.2      0.9  
Fold gap inc1-153 None      0 

*PT, prior to treatment.

†

Gaps = Total Area − Cell Area.

‡

% Gaps = Gaps ÷ Total Area.

F1-153

Fold gap inc = [% Gaps (at Time Point) − % Gaps (at PT)] ÷ % Gaps (at PT).

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