The Ribozyme Rzd Inhibits TNF and GM-CSF, But Not IL-1β Production in JMML Cells
| Compound . | Cytokine (pg/mL) . | ||
|---|---|---|---|
| TNFα . | GM-CSF . | IL-1β . | |
| None | 55.5 ± 4.5 | 64.5 ± 8.0 | 11.5 ± 2.5 |
| Only liposome (DOTAP) | 58.6 ± 3.6 | 68.6 ± 8.6 | 13.6 ± 1.6 |
| Ribozyme Rzd | 16.3 ± 2.4 | 26.5 ± 5.7 | 16.0 ± 2.1 |
| Ribozyme Rzdm | 30.6 ± 4.4 | 50.7 ± 7.8 | 14.1 ± 2.4 |
| Compound . | Cytokine (pg/mL) . | ||
|---|---|---|---|
| TNFα . | GM-CSF . | IL-1β . | |
| None | 55.5 ± 4.5 | 64.5 ± 8.0 | 11.5 ± 2.5 |
| Only liposome (DOTAP) | 58.6 ± 3.6 | 68.6 ± 8.6 | 13.6 ± 1.6 |
| Ribozyme Rzd | 16.3 ± 2.4 | 26.5 ± 5.7 | 16.0 ± 2.1 |
| Ribozyme Rzdm | 30.6 ± 4.4 | 50.7 ± 7.8 | 14.1 ± 2.4 |
Triplicate measurements were made from each of the three patients, and the obtained median values were used to calculate the mean ± SEM shown in the table.