Dose-Response With IFN-A Therapy in CML
| Study (reference) . | Dose Schedule . | No. . | % CHR . | % Cytogenetic Response . | ||
|---|---|---|---|---|---|---|
| Any . | Major . | Complete . | ||||
| MDACC (2) | 5 MU/m2/d | 274 | 80 | 58 | 38 | 26 |
| Gastl (7) | 0.6-2.5 MU/m2/d | 10 | 10 | 0 | 0 | 0 |
| Anger (5) | 3 MU TIW | 9 | 22 | 0 | 0 | 0 |
| Freund (6) | 3 MU/m2 (5 MU) TIW | 27 | 37 | 18 | 0 | 0 |
| Alimena (4) | 2 MU/m2 TIW | 33 | 24 | — | — | |
| 5 MU/m2 TIW | 30 | 63 | — | — | ||
| Thaler (8) | 2 MU/m2/d (3.5 MU/d) | 77 | 39 | 28 | 13 | 8 |
| Schofield (10) | 2 MU/m2 TIW | 27 | 70 | 33 | 22 | 7 |
| Study (reference) . | Dose Schedule . | No. . | % CHR . | % Cytogenetic Response . | ||
|---|---|---|---|---|---|---|
| Any . | Major . | Complete . | ||||
| MDACC (2) | 5 MU/m2/d | 274 | 80 | 58 | 38 | 26 |
| Gastl (7) | 0.6-2.5 MU/m2/d | 10 | 10 | 0 | 0 | 0 |
| Anger (5) | 3 MU TIW | 9 | 22 | 0 | 0 | 0 |
| Freund (6) | 3 MU/m2 (5 MU) TIW | 27 | 37 | 18 | 0 | 0 |
| Alimena (4) | 2 MU/m2 TIW | 33 | 24 | — | — | |
| 5 MU/m2 TIW | 30 | 63 | — | — | ||
| Thaler (8) | 2 MU/m2/d (3.5 MU/d) | 77 | 39 | 28 | 13 | 8 |
| Schofield (10) | 2 MU/m2 TIW | 27 | 70 | 33 | 22 | 7 |
Abbreviation: TIW, 3 times weekly.