Ph+ ALL Patients From Trials ALL-BFM 86 and 90 and AIEOP 8803 and 9103
| Patient No. . | Sex . | Age (yr) . | WBC (×106/L) . | IM (My+) . | Diagnosis Ph+ Based on CG/MG . | PGR . | CT Protocol . | Rem. Induction . | BMT in 1.CR/PR . | Relapse (type, time)* . | Status, Time* . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 12.1 | 410,000 | c | CG | No | 86-EG | NR | DOD +1 | ||
| 2 | F | 5.4 | 119,000 | c (+) | CG | No | 86-EG | NR | DOD +19 | ||
| 3 | M | 13.5 | 243,000 | c | CG/m-BCR | No | 90-HR | LR | MMRD +8 | BM +10 | DOD +11 |
| 4 | M | 14 | 139,800 | c | CG | No | 90-HR | NR (CR pBMT) | MRD +4 in PR | BM +12 | DOD +13 |
| 5 | F | 7.5 | 23,100 | c (+) | CG/m-BCR | No | 90-HR | CR | BM +10 | DOD +13 | |
| 6 | M | 9 | 110,000 | c | CG/m-BCR | No | 90-HR | LR | BM +21 | DOD +23 | |
| 7 | M | 13 | 96,400 | c (+) | CG/M-BCR | No | 90-HR | CR | MRD +6 | +11 dead post BMT | |
| 8 | M | 2.5 | 7,350 | c | m-BCR | No | 90-HR | CR | MURD +14 | +16 dead post BMT | |
| 9 | M | 7 | 270,000 | c (+) | CG/MG− | No | 90-HR | LR | BM +9 | DOD +14 | |
| 10 | F | 15.5 | 199,000 | c | CG | No | 90-HR | NR (CR pBMT) | MRD +5 in PR | BM/skin +17 | DOD +20 |
| 11 | F | 3.1 | 6,200 | c (+) | CG/M-BCR | No | 90-MR | CR | BM +10 | DOD +11 | |
| 12 | M | 13 | 101,000 | c | CG/m-BCR | No | 90-HR | CR | BM +13 | DOD +19 | |
| 13 | M | 6.64 | 436,800 | c | CG/m-BCR | No | 9103 | NR (CR pBMT) | MRD +4 in PR | CR1 75+ | |
| 14 | F | 6.8 | 236,000 | c (+) | m-BCR | No | 9103 | NR (CR pBMT) | MRD +3 in PR | +5 dead post BMT | |
| 15 | M | 12.6 | 50,800 | ppB | M-BCR | No | 9103 | NR | DOD +10 | ||
| 16 | M | 12.9 | 277,000 | pB | m-BCR | No | 9103 | NR | DOD +17 | ||
| 17 | M | 14.9 | 572,200 | T (+) | CG/M-BCR | No | 9103 | NR | DOD +21 | ||
| 18 | F | 11.1 | 404,900 | c (+) | CG/m-BCR | No | 8803 | LR | MRD +5 | CR1 92+ | |
| 19 | F | 5.6 | 81,000 | c | CG/m-BCR | No | 8803 | CR | BM +3 | DOD +11 | |
| 20 | F | 7.1 | 150,000 | c | CG | No | 8803 | LR | BM/CNS +17 | DOD +21 | |
| 21 | M | 7.1 | 12,100 | pB | CG | Yes | 86-RG | CR | BM +32 | CR2 120+ (BMT +36) | |
| 22 | F | 8.3 | 173,306 | c | CG | Yes | 86-RG | CR | CR1 95+ | ||
| 23 | M | 7.9 | 75,000 | c | CG | Yes | 86-RG | CR | BM +10 | DOD +17 | |
| 24 | M | 12.9 | 27,700 | c | CG | Yes | 86-RG | CR | BM +31 | CR3 94+ (2. rel. +83, MURD +87) | |
| 25 | M | 6 | 107,800 | c | CG | Yes | 86-RG | CR | BM +5 | DOD +8 | |
| 26 | F | 5 | 2,200 | c | CG/M-BCR | Yes | 90-HR | CR | MMRD +7 | +9 dead post BMT | |
| 27 | M | 10 | 210,900 | c | CG/m-BCR | Yes | 90-HR | CR | MMRD +5 | Testes +16 | CR2 59+ |
| 28 | F | 4.8 | 6,900 | c | m-BCR | Yes | 90-HR | CR | CR1 53+ | ||
| 29 | M | 4.7 | 14,800 | c | CG/m-BCR | Yes | 90-HR | CR | MMURD +29† | +32 dead post BMT | |
| 30 | M | 4 | 72,800 | c | CG | Yes | 90-HR | CR | CR1 80+ | ||
| 31 | M | 13 | 13,700 | c (+) | CG | Yes | 90-HR | CR | BM +17 | CR2 30+ | |
| 32 | F | 10.1 | 44,300 | c | CG−/m-BCR | Yes | 90-HR | CR | MRD +4 | CR1 50+ | |
| 33 | M | 8.3 | 257,000 | T (+) | CG/m-BCR | Yes | 90-HR | CR | BM +6 | DOD +10 | |
| 34 | F | 2.2 | 74,300 | pB | CG/M-BCR | Yes | 90-HR | CR | CR1 29+ | ||
| 35 | F | 15.5 | 2,400 | c | m-BCR | Yes | 90-HR | CR | MRD +5 | CR1 47+ | |
| 36 | M | 5 | 128,000 | c | CG | Yes | 90-HR | CR | BM +7 | DOD +11 | |
| 37 | M | 7 | 29,000 | pB | CG/M-BCR | Yes | 90-HR | CR | MRD +32‡ | CR1 53+ | |
| 38 | M | 2.5 | 46,700 | pB | CG/m-BCR | Yes | 90-HR | CR | MRD +7 | CR1 35+ | |
| 39 | M | 12.3 | 109,000 | c | CG/m-BCR | Yes | 90-HR | CR | MRD +4 | CR1 53+ | |
| 40 | F | 3.5 | 22,000 | c | CG/m-BCR | Yes | 90-HR | CR | MRD +6 | CR1 43+ | |
| 41 | M | 3.1 | 53,000 | c | m-BCR | Yes | 90-HR | CR | MRD +6 | CR1 51+ | |
| 42 | M | 8.7 | 99,400 | pB | CG/m-BCR | Yes | 90-HR | CR | BM +38 | CR2 41+ | |
| 43 | M | 3 | 8,300 | c | m-BCR | Yes | 90-HR | CR | MURD +11 | +13 dead post BMT | |
| 44 | M | 7.5 | 8,600 | c (+) | CG/m-BCR | Yes | 90-HR | CR | BM/bone +11 | DOD +17 (post MRD +12) | |
| 45 | M | 9.5 | 163,500 | c | CG/m-BCR | Yes | 9103 | CR | MRD +6 | CR1 52+ | |
| 46 | F | 13 | 18,000 | c (+) | M-BCR | Yes | 9103 | CR | MURD +9 | +14 dead post BMT | |
| 47 | M | 1.5 | 8,700 | c (+) | m-BCR | Yes | 9103 | CR | CR1 30+ | ||
| 48 | M | 6.7 | 5,400 | c | CG | Yes | 9103 | CR | MRD +6 | CR1 55+ | |
| 49 | F | 3.1 | 35,700 | pB | CG/m-BCR | Yes | 9103 | CR | MRD +6 | CR1 57+ | |
| 50 | M | 8.3 | 9,740 | pB | CG/m-BCR | Yes | 9103 | CR | MRD +6 | CR1 51+ | |
| 51 | M | 1.2 | 7,200 | pB | CG | Yes | 9103 | CR | CR1 47+ | ||
| 52 | M | 8.6 | 18,000 | c | CG | Yes | 9103 | CR | MRD +14 | CR1 43+ | |
| 53 | F | 10 | 11,000 | c | CG | Yes | 9103 | CR | CR1 39+ | ||
| 54 | M | 9.8 | 210,000 | c | CG/M-BCR | Yes | 9103 | CR | MURD +25 | CR1 31+ | |
| 55 | M | 4.1 | 450,000 | c | CG/m-BCR | Yes | 8803 | CR | BM +7 | DOD +14 | |
| 56 | F | 2.8 | 18,660 | c | CG/m-BCR | Yes | 8803 | CR | (auto +24) | CR1 110+ | |
| 57 | M | 4.7 | 304,000 | c | CG | Yes | 8803 | CR | BM +34 | +82 dead of inf. (after 2. rel. +60, MURD +62) | |
| 58 | F | 16.6 | 61,300 | c | CG | NE | 90-MR | CR | MRD +5 | CR1 36+ | |
| 59 | M | 8.1 | 75,700 | T (+) | CG/M-BCR | NE | 90-HR | CR | BM +12 | DOD +20 (post BMT +15) | |
| 60 | M | 9.4 | 372,600 | c (+) | CG | NE | 9103 | NR | MMRD +10 in PR | +11 dead post BMT | |
| 61 | F | 7.4 | 560,000 | pB | m-BCR | NE | 9103 | CR | BM +6 | +14 dead (after MMRD) |
| Patient No. . | Sex . | Age (yr) . | WBC (×106/L) . | IM (My+) . | Diagnosis Ph+ Based on CG/MG . | PGR . | CT Protocol . | Rem. Induction . | BMT in 1.CR/PR . | Relapse (type, time)* . | Status, Time* . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 12.1 | 410,000 | c | CG | No | 86-EG | NR | DOD +1 | ||
| 2 | F | 5.4 | 119,000 | c (+) | CG | No | 86-EG | NR | DOD +19 | ||
| 3 | M | 13.5 | 243,000 | c | CG/m-BCR | No | 90-HR | LR | MMRD +8 | BM +10 | DOD +11 |
| 4 | M | 14 | 139,800 | c | CG | No | 90-HR | NR (CR pBMT) | MRD +4 in PR | BM +12 | DOD +13 |
| 5 | F | 7.5 | 23,100 | c (+) | CG/m-BCR | No | 90-HR | CR | BM +10 | DOD +13 | |
| 6 | M | 9 | 110,000 | c | CG/m-BCR | No | 90-HR | LR | BM +21 | DOD +23 | |
| 7 | M | 13 | 96,400 | c (+) | CG/M-BCR | No | 90-HR | CR | MRD +6 | +11 dead post BMT | |
| 8 | M | 2.5 | 7,350 | c | m-BCR | No | 90-HR | CR | MURD +14 | +16 dead post BMT | |
| 9 | M | 7 | 270,000 | c (+) | CG/MG− | No | 90-HR | LR | BM +9 | DOD +14 | |
| 10 | F | 15.5 | 199,000 | c | CG | No | 90-HR | NR (CR pBMT) | MRD +5 in PR | BM/skin +17 | DOD +20 |
| 11 | F | 3.1 | 6,200 | c (+) | CG/M-BCR | No | 90-MR | CR | BM +10 | DOD +11 | |
| 12 | M | 13 | 101,000 | c | CG/m-BCR | No | 90-HR | CR | BM +13 | DOD +19 | |
| 13 | M | 6.64 | 436,800 | c | CG/m-BCR | No | 9103 | NR (CR pBMT) | MRD +4 in PR | CR1 75+ | |
| 14 | F | 6.8 | 236,000 | c (+) | m-BCR | No | 9103 | NR (CR pBMT) | MRD +3 in PR | +5 dead post BMT | |
| 15 | M | 12.6 | 50,800 | ppB | M-BCR | No | 9103 | NR | DOD +10 | ||
| 16 | M | 12.9 | 277,000 | pB | m-BCR | No | 9103 | NR | DOD +17 | ||
| 17 | M | 14.9 | 572,200 | T (+) | CG/M-BCR | No | 9103 | NR | DOD +21 | ||
| 18 | F | 11.1 | 404,900 | c (+) | CG/m-BCR | No | 8803 | LR | MRD +5 | CR1 92+ | |
| 19 | F | 5.6 | 81,000 | c | CG/m-BCR | No | 8803 | CR | BM +3 | DOD +11 | |
| 20 | F | 7.1 | 150,000 | c | CG | No | 8803 | LR | BM/CNS +17 | DOD +21 | |
| 21 | M | 7.1 | 12,100 | pB | CG | Yes | 86-RG | CR | BM +32 | CR2 120+ (BMT +36) | |
| 22 | F | 8.3 | 173,306 | c | CG | Yes | 86-RG | CR | CR1 95+ | ||
| 23 | M | 7.9 | 75,000 | c | CG | Yes | 86-RG | CR | BM +10 | DOD +17 | |
| 24 | M | 12.9 | 27,700 | c | CG | Yes | 86-RG | CR | BM +31 | CR3 94+ (2. rel. +83, MURD +87) | |
| 25 | M | 6 | 107,800 | c | CG | Yes | 86-RG | CR | BM +5 | DOD +8 | |
| 26 | F | 5 | 2,200 | c | CG/M-BCR | Yes | 90-HR | CR | MMRD +7 | +9 dead post BMT | |
| 27 | M | 10 | 210,900 | c | CG/m-BCR | Yes | 90-HR | CR | MMRD +5 | Testes +16 | CR2 59+ |
| 28 | F | 4.8 | 6,900 | c | m-BCR | Yes | 90-HR | CR | CR1 53+ | ||
| 29 | M | 4.7 | 14,800 | c | CG/m-BCR | Yes | 90-HR | CR | MMURD +29† | +32 dead post BMT | |
| 30 | M | 4 | 72,800 | c | CG | Yes | 90-HR | CR | CR1 80+ | ||
| 31 | M | 13 | 13,700 | c (+) | CG | Yes | 90-HR | CR | BM +17 | CR2 30+ | |
| 32 | F | 10.1 | 44,300 | c | CG−/m-BCR | Yes | 90-HR | CR | MRD +4 | CR1 50+ | |
| 33 | M | 8.3 | 257,000 | T (+) | CG/m-BCR | Yes | 90-HR | CR | BM +6 | DOD +10 | |
| 34 | F | 2.2 | 74,300 | pB | CG/M-BCR | Yes | 90-HR | CR | CR1 29+ | ||
| 35 | F | 15.5 | 2,400 | c | m-BCR | Yes | 90-HR | CR | MRD +5 | CR1 47+ | |
| 36 | M | 5 | 128,000 | c | CG | Yes | 90-HR | CR | BM +7 | DOD +11 | |
| 37 | M | 7 | 29,000 | pB | CG/M-BCR | Yes | 90-HR | CR | MRD +32‡ | CR1 53+ | |
| 38 | M | 2.5 | 46,700 | pB | CG/m-BCR | Yes | 90-HR | CR | MRD +7 | CR1 35+ | |
| 39 | M | 12.3 | 109,000 | c | CG/m-BCR | Yes | 90-HR | CR | MRD +4 | CR1 53+ | |
| 40 | F | 3.5 | 22,000 | c | CG/m-BCR | Yes | 90-HR | CR | MRD +6 | CR1 43+ | |
| 41 | M | 3.1 | 53,000 | c | m-BCR | Yes | 90-HR | CR | MRD +6 | CR1 51+ | |
| 42 | M | 8.7 | 99,400 | pB | CG/m-BCR | Yes | 90-HR | CR | BM +38 | CR2 41+ | |
| 43 | M | 3 | 8,300 | c | m-BCR | Yes | 90-HR | CR | MURD +11 | +13 dead post BMT | |
| 44 | M | 7.5 | 8,600 | c (+) | CG/m-BCR | Yes | 90-HR | CR | BM/bone +11 | DOD +17 (post MRD +12) | |
| 45 | M | 9.5 | 163,500 | c | CG/m-BCR | Yes | 9103 | CR | MRD +6 | CR1 52+ | |
| 46 | F | 13 | 18,000 | c (+) | M-BCR | Yes | 9103 | CR | MURD +9 | +14 dead post BMT | |
| 47 | M | 1.5 | 8,700 | c (+) | m-BCR | Yes | 9103 | CR | CR1 30+ | ||
| 48 | M | 6.7 | 5,400 | c | CG | Yes | 9103 | CR | MRD +6 | CR1 55+ | |
| 49 | F | 3.1 | 35,700 | pB | CG/m-BCR | Yes | 9103 | CR | MRD +6 | CR1 57+ | |
| 50 | M | 8.3 | 9,740 | pB | CG/m-BCR | Yes | 9103 | CR | MRD +6 | CR1 51+ | |
| 51 | M | 1.2 | 7,200 | pB | CG | Yes | 9103 | CR | CR1 47+ | ||
| 52 | M | 8.6 | 18,000 | c | CG | Yes | 9103 | CR | MRD +14 | CR1 43+ | |
| 53 | F | 10 | 11,000 | c | CG | Yes | 9103 | CR | CR1 39+ | ||
| 54 | M | 9.8 | 210,000 | c | CG/M-BCR | Yes | 9103 | CR | MURD +25 | CR1 31+ | |
| 55 | M | 4.1 | 450,000 | c | CG/m-BCR | Yes | 8803 | CR | BM +7 | DOD +14 | |
| 56 | F | 2.8 | 18,660 | c | CG/m-BCR | Yes | 8803 | CR | (auto +24) | CR1 110+ | |
| 57 | M | 4.7 | 304,000 | c | CG | Yes | 8803 | CR | BM +34 | +82 dead of inf. (after 2. rel. +60, MURD +62) | |
| 58 | F | 16.6 | 61,300 | c | CG | NE | 90-MR | CR | MRD +5 | CR1 36+ | |
| 59 | M | 8.1 | 75,700 | T (+) | CG/M-BCR | NE | 90-HR | CR | BM +12 | DOD +20 (post BMT +15) | |
| 60 | M | 9.4 | 372,600 | c (+) | CG | NE | 9103 | NR | MMRD +10 in PR | +11 dead post BMT | |
| 61 | F | 7.4 | 560,000 | pB | m-BCR | NE | 9103 | CR | BM +6 | +14 dead (after MMRD) |
Patients are listed according to prednisone response and by protocol applied.
Abbreviations: c, common ALL; CG, cytogenetics positive for t(9;22); CG−, translocation t(9;22) not detected; CT, chemotherapy; DOD, died of disease; IDN, identification number; IM, immunophenotype; LR, late response, no remission after induction (phase 1 of protocol I); MG, molecular genetics positive for BCR/ABL; MG−, BCR/ABL not detected (false-negative at first diagnosis, but positive at relapse); m-BCR, M-BCR, minor/major breakpoint cluster region, see text; (M)M(U)RD, allogeneic HLA-(mis)matched (un)-related donor BMT; My+, ≥1 myeloid marker positive; NE, not evaluable; NR, nonresponse; rel., relapse; rem., remission; pB, pre-B ALL; ppB, pre-pre B ALL; PGR, prednisone good response; PR, partial remission; T, T-ALL.
*Time from diagnosis (months).
†BCR/ABL positive at +22 months.
‡BCR/ABL positive at +25 months.