SCID mice were first injected subcutaneously with low-density CML cells containing 1.5 × 10⁶ CD34⁺ cells per animal admixed with matrigel. Four weeks later some animals received 4 × 10⁷ autologous CIK cells either derived from bone marrow or peripheral blood. Animals were killed 14 weeks later and analyzed for the presence of bcr/abl transcripts by RT-PCR from RNA extracted from PB, bone marrow, and spleen.

Indicates that the CIK-treated animals were less likely to have positive RT-PCR results (P = .02).