Growth of Normal and Leukemic CFU-GM Colonies in the Presence and Absence of Allogeneic CIK Cells
| Cells . | Percent CD3+CD56+ . | M.B. (normal) . | P.S. (NHL) . | M.R. (CML) . |
|---|---|---|---|---|
| Targets alone | — | 100 | 100 | 100 |
| CIK-1 | 32 | 93.7 | 218.2 | 50.8* |
| CIK-2 | 40 | 92.6 | 213.6 | 62.7† |
| CIK-3 | 27 | 86.3 | 218.2 | 55.6* |
| Cells . | Percent CD3+CD56+ . | M.B. (normal) . | P.S. (NHL) . | M.R. (CML) . |
|---|---|---|---|---|
| Targets alone | — | 100 | 100 | 100 |
| CIK-1 | 32 | 93.7 | 218.2 | 50.8* |
| CIK-2 | 40 | 92.6 | 213.6 | 62.7† |
| CIK-3 | 27 | 86.3 | 218.2 | 55.6* |
Results are representative of three experiments and are expressed as the percentage of CFU-GM growth to that of targets alone. The number of CFU-GM colonies for MB (normal donor) was 95 ± 12.7, for P.S. (non-Hodgkin’s lymphoma) 22 ± 4.6 colonies, and for M.R. (CML patient) 333 ± 71.9 colonies. All experiments were performed in triplicate. CIK cells were prepared from buffy coats of three normal donors.
P < .05.
P = .07.