Prognostic Factors of ATRA Syndrome in 413 Cases of Newly Diagnosed APL Included in APL 93 Trial
| . | Absence of ATRA Syndrome . | ATRA Syndrome . | P Value . |
|---|---|---|---|
| No. of patients | 349 | 64 | |
| M/F | 169/176 (0.95) | 36/28 (1.3) | .34 |
| Mean age | 46 | 44 | .33 |
| WBC (109/L) | |||
| Mean | 10.9 | 11.9 | .7 |
| <5.0 | 213 (61%) | 34 (53%) | .26 |
| 5.0 to 10.0 | 42 (12%) | 13 (20%) | 1.0 |
| 10.0 to 20.0 | 31 (9%) | 5 (8%) | ND |
| >20.0 | 63 (18%) | 12 (19%) | .85 |
| Mean platelet count (109/L) | 44 | 40 | .27 |
| Mean circulating blasts (109/L) | 7.7 | 8.0 | .09 |
| Mean fibrinogen level (g/L) | 1.9 | 1.7 | .47 |
| Microgranular variant APL | 16% | 19% | .57 |
| PML/RARα isoform (124 patients) | |||
| bcr1 | 80 (64%) | 12 (57%) | .3 |
| bcr2 | 2 (2%) | ||
| bcr3 | 42 (34%) | 9 (43%) | |
| Induction group | |||
| ATRA → CT | 89 (82%) | 20 (18%) | |
| ATRA + CT | 88 (89%) | 11 (11%) | P = .17 |
| High WBC group | 134 (82%) | 29 (18%) | |
| Elderly group | 38 (90%) | 4 (10%) |
| . | Absence of ATRA Syndrome . | ATRA Syndrome . | P Value . |
|---|---|---|---|
| No. of patients | 349 | 64 | |
| M/F | 169/176 (0.95) | 36/28 (1.3) | .34 |
| Mean age | 46 | 44 | .33 |
| WBC (109/L) | |||
| Mean | 10.9 | 11.9 | .7 |
| <5.0 | 213 (61%) | 34 (53%) | .26 |
| 5.0 to 10.0 | 42 (12%) | 13 (20%) | 1.0 |
| 10.0 to 20.0 | 31 (9%) | 5 (8%) | ND |
| >20.0 | 63 (18%) | 12 (19%) | .85 |
| Mean platelet count (109/L) | 44 | 40 | .27 |
| Mean circulating blasts (109/L) | 7.7 | 8.0 | .09 |
| Mean fibrinogen level (g/L) | 1.9 | 1.7 | .47 |
| Microgranular variant APL | 16% | 19% | .57 |
| PML/RARα isoform (124 patients) | |||
| bcr1 | 80 (64%) | 12 (57%) | .3 |
| bcr2 | 2 (2%) | ||
| bcr3 | 42 (34%) | 9 (43%) | |
| Induction group | |||
| ATRA → CT | 89 (82%) | 20 (18%) | |
| ATRA + CT | 88 (89%) | 11 (11%) | P = .17 |
| High WBC group | 134 (82%) | 29 (18%) | |
| Elderly group | 38 (90%) | 4 (10%) |
Abbreviation: ND, not done.