Table 3. Cytokine Production by... | American Society of Hematology

Table 3.

Cytokine Production by bcr-abl–Specific CD4⁺ T-Cell Clones

Cells Cultured	Peptide Stimulation	Cytokine Production (pg/mL)^*
Cells Cultured	Peptide Stimulation	IL-3	IL-4	IL-10	TNF-α	IFN-γ	GM-CSF
MY-1 + auto APC	None	0	0	5	39	57	115
	b3a2	131	504	1,324	953	2,756	1,786
MY auto APC alone	b3a2	0	0	16	84	4	11
TO-1 + auto APC	None	7	0	77	93	59	8
	b3a2	141	442	1,557	654	3,115	1,815
TO auto APC alone	b3a2	0	0	13	94	51	16

Cells Cultured	Peptide Stimulation	Cytokine Production (pg/mL)^*
Cells Cultured	Peptide Stimulation	IL-3	IL-4	IL-10	TNF-α	IFN-γ	GM-CSF
MY-1 + auto APC	None	0	0	5	39	57	115
	b3a2	131	504	1,324	953	2,756	1,786
MY auto APC alone	b3a2	0	0	16	84	4	11
TO-1 + auto APC	None	7	0	77	93	59	8
	b3a2	141	442	1,557	654	3,115	1,815
TO auto APC alone	b3a2	0	0	13	94	51	16

Abbreviation: auto, autologous.

T-cell clones were cultured in the presence of autologous APCs with and without b3a2 synthetic peptide for 72 hours, and the concentration of each cytokine in the culture supernatant was determined by ELISA.

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