FXI, FXII, and PK Antigen Levels After LPS Infusion to Volunteers
| . | t = 0 . | t = 1 . | t = 2 . | t = 3 . | t = 4 . | t = 6 . | t = 24 . | P Value . |
|---|---|---|---|---|---|---|---|---|
| FXI:Ag | 100 | 106 ± 4.2 | 98 ± 4.2 | 92 ± 4.1 | 91 ± 3.7 | 90 ± 3.3 | 101 ± 5.6 | .003 |
| FXII:Ag | 100 | 100 ± 4.4 | 99 ± 4.3 | 108 ± 6.8 | 100 ± 5.2 | 100 ± 5.2 | 110 ± 9 | .3 |
| PK:Ag | 100 | 104 ± 4.8 | 101 ± 2.7 | 108 ± 7.6 | 102 ± 6.1 | 103 ± 4.1 | 97 ± 7.2 | .6 |
| . | t = 0 . | t = 1 . | t = 2 . | t = 3 . | t = 4 . | t = 6 . | t = 24 . | P Value . |
|---|---|---|---|---|---|---|---|---|
| FXI:Ag | 100 | 106 ± 4.2 | 98 ± 4.2 | 92 ± 4.1 | 91 ± 3.7 | 90 ± 3.3 | 101 ± 5.6 | .003 |
| FXII:Ag | 100 | 100 ± 4.4 | 99 ± 4.3 | 108 ± 6.8 | 100 ± 5.2 | 100 ± 5.2 | 110 ± 9 | .3 |
| PK:Ag | 100 | 104 ± 4.8 | 101 ± 2.7 | 108 ± 7.6 | 102 ± 6.1 | 103 ± 4.1 | 97 ± 7.2 | .6 |
Antigen levels of FXI, FXII, and PK were measured using ELISAs (see Materials and Methods). Baseline values before LPS infusion (4 ng/kg) from eight volunteers (t = 0) were set at 100%, and changes over time, expressed as mean ± SEM, were analyzed with one-way analysis of variance.