Table 2. Modulation of Caspase 3... | American Society of Hematology

Table 2.

Modulation of Caspase 3 Activity by DOX and CD40L

Culture Conditions		Caspase 3 Activity (U/2 × 10⁵cells)
DOX (μg/mL)	L Cells	Daudi	Raji	BJAB	BL36	BL70
—	—	5.8	2.42	1.97	4.52	0.32
0.1	—	4.57	2.33	5.35^*	5.21^*	0.69^*
0.1	CD40L	4.49	1.85	2.62^†	1.77^†	0.43^†
0.5	—	7.22^*	5.33^*	12.07^*	8.6^*	2.71^*
0.5	CD40L	4.97^†	3.25^†	6.27^†	5.94^†	0.94^†
1	—	8.28^*	6.79^*	13.33^*	9.1^*	3.54^*
1	CD40L	7.69	5.53	5.92^†	8.68	1.45^†
0.5	CDw32	7.26^*	8.56^*	14.12^*	8.71^*	4.34^*
0.5	INH^‡	0^*	0^*	0^*	0^*	0^*

Culture Conditions		Caspase 3 Activity (U/2 × 10⁵cells)
DOX (μg/mL)	L Cells	Daudi	Raji	BJAB	BL36	BL70
—	—	5.8	2.42	1.97	4.52	0.32
0.1	—	4.57	2.33	5.35^*	5.21^*	0.69^*
0.1	CD40L	4.49	1.85	2.62^†	1.77^†	0.43^†
0.5	—	7.22^*	5.33^*	12.07^*	8.6^*	2.71^*
0.5	CD40L	4.97^†	3.25^†	6.27^†	5.94^†	0.94^†
1	—	8.28^*	6.79^*	13.33^*	9.1^*	3.54^*
1	CD40L	7.69	5.53	5.92^†	8.68	1.45^†
0.5	CDw32	7.26^*	8.56^*	14.12^*	8.71^*	4.34^*
0.5	INH^‡	0^*	0^*	0^*	0^*	0^*

*P < .05 (Student’s paired t-test) as compared with culture without DOX in 7 experiments.

P < .05 (Student’s paired t-test) as compared with cells treated with DOX in 7 experiments.

Caspase 3 inhibitor (tetrapeptide DEVD-CHO, 50 μmol/L).