Table 1. Experimental Parameters Patient... | American Society of Hematology

Table 1.

Experimental Parameters

Patient No.	Stage^*	Prior Therapy	Isotype	Cells (×10⁶) Inoculated^-151	Plasma Cells (%)^-152	Weeks to hIg Detection^-153	Weeks to End of Experiment^-155	Final hIg Levels (μg/ml)¶
1	III A	21 mo	IgG κ	3	78	2	17	IgG = 657 κ = 458
2	III A	2 mo	IgA κ	3	40	19	25	IgA = 504 κ = 341
3	III A	None#	IgG κ	3	26	9	36	IgG = 130 κ = 330
4	III A	12 mo	IgA κ	2	35	6	12	IgA = 365 κ = 1415
5	II A	26 mo	Nonsecretor	4	20		29	None detected
6	III A	None	κ light chain	5	75	9	29	κ = 560
7	I A	None	IgG κ	10	11	2	15	IgG = 16 κ = 230
8	III B	None	κ light chain	1.5	42		36	None detected
9	III A	None	IgA κ	3	35		>23^-160	None detected
10	II A	4 mo	IgA λ	5	25	4	>15	IgG = 88 IgA = 173 κ = 75 λ = 137
11	III A	>24 mo	IgG λ	5	12	4	>15	IgG = 50 λ = 2
12	II A	4 mo	IgG κ	6	20	2	12	IgG = 2100 κ = 3600
13	III A	None	IgG κ	5	30	3	>12	IgG = 2100 κ = 1700
14	III B	>24 mo	IgG κ	6	23	2	>7	IgG = 360 κ = 500
15	II A	10 mo	Nonsecretor	5	89	3	>3	IgG = 156 κ = 334

Patient No.	Stage^*	Prior Therapy	Isotype	Cells (×10⁶) Inoculated^-151	Plasma Cells (%)^-152	Weeks to hIg Detection^-153	Weeks to End of Experiment^-155	Final hIg Levels (μg/ml)¶
1	III A	21 mo	IgG κ	3	78	2	17	IgG = 657 κ = 458
2	III A	2 mo	IgA κ	3	40	19	25	IgA = 504 κ = 341
3	III A	None#	IgG κ	3	26	9	36	IgG = 130 κ = 330
4	III A	12 mo	IgA κ	2	35	6	12	IgA = 365 κ = 1415
5	II A	26 mo	Nonsecretor	4	20		29	None detected
6	III A	None	κ light chain	5	75	9	29	κ = 560
7	I A	None	IgG κ	10	11	2	15	IgG = 16 κ = 230
8	III B	None	κ light chain	1.5	42		36	None detected
9	III A	None	IgA κ	3	35		>23^-160	None detected
10	II A	4 mo	IgA λ	5	25	4	>15	IgG = 88 IgA = 173 κ = 75 λ = 137
11	III A	>24 mo	IgG λ	5	12	4	>15	IgG = 50 λ = 2
12	II A	4 mo	IgG κ	6	20	2	12	IgG = 2100 κ = 3600
13	III A	None	IgG κ	5	30	3	>12	IgG = 2100 κ = 1700
14	III B	>24 mo	IgG κ	6	23	2	>7	IgG = 360 κ = 500
15	II A	10 mo	Nonsecretor	5	89	3	>3	IgG = 156 κ = 334

*Stage according to the Durie Salmon staging.

Total number of bone marrow cells inoculated.

Percentage of plasma cells in inoculates as determined by CD38/CD45 flow cytometry.

Time from myeloma bone marrow cells inoculation, measured in weeks.

Experiments were ended when monotypic hIg levels were ≥200 μg/mL.

¶Human Ig levels in the mouse serum at the end of experiment as measured by ELISA.

#Newly diagnosed patients.

Experiment still underway.