Adhesion of Most Dense and Least Dense Sickle RBC Fractions to Immobilized Laminin
| Fraction . | Adherent Cells/mm2 ± SD . |
|---|---|
| Least dense | 335.8 ± 75.0 |
| Most dense | 2,662.5 ± 366.6 |
| Fraction . | Adherent Cells/mm2 ± SD . |
|---|---|
| Least dense | 335.8 ± 75.0 |
| Most dense | 2,662.5 ± 366.6 |
SS RBC fractions were separated by density on arabinogalactan gradients. Equal numbers of cells in each fraction were used in the flow adhesion assay. Denser, reticulocyte-depleted RBCs were approximately nine times more adhesive to hLAM than the least dense, reticulocyte-enriched fraction. Data from 4 patients are shown.