Quantitation of Marker DNA and Expression
| Type of Bone Marrow Transduced and Transplanted . | Cytopenic Early Posttransplant Period-150 . | Postengraftment Period-151 . | Late Follow-Up Period-152 . | Postimmunosuppressive Treatment . | ||||
|---|---|---|---|---|---|---|---|---|
| PCR % TBL-153 . | IF % LYM-155 . | PCR % TBL . | IF % LYM . | PCR % TBL . | IF % LYM . | PCR % TBL . | IF % LYM . | |
| No cytokine pretreatment | 2 ± 1¶ | 30 ± 7 | 1.4 ± 1 | 0 | NA | 0 | NA | NA |
| Cytokine pretreated autologous | 7 ± 2 | 18 ± 2 | 10 ± 2 | 1 ± 1 | 2 ± 1 | 0 | NA | 11 ± 4 |
| Cytokine pretreated allogeneic | 19# | 30 ± 7 | 28# | 25 ± 5 | 19 ± 2 | 34 ± 24 | 20 ± 4 | 19 ± 4 |
| Type of Bone Marrow Transduced and Transplanted . | Cytopenic Early Posttransplant Period-150 . | Postengraftment Period-151 . | Late Follow-Up Period-152 . | Postimmunosuppressive Treatment . | ||||
|---|---|---|---|---|---|---|---|---|
| PCR % TBL-153 . | IF % LYM-155 . | PCR % TBL . | IF % LYM . | PCR % TBL . | IF % LYM . | PCR % TBL . | IF % LYM . | |
| No cytokine pretreatment | 2 ± 1¶ | 30 ± 7 | 1.4 ± 1 | 0 | NA | 0 | NA | NA |
| Cytokine pretreated autologous | 7 ± 2 | 18 ± 2 | 10 ± 2 | 1 ± 1 | 2 ± 1 | 0 | NA | 11 ± 4 |
| Cytokine pretreated allogeneic | 19# | 30 ± 7 | 28# | 25 ± 5 | 19 ± 2 | 34 ± 24 | 20 ± 4 | 19 ± 4 |
Abbreviation: NA, no measurement available.
1 to 5 weeks.
6 to 15 weeks.
16 to 37 weeks.
Percent of total blood leukocytes carring retroviral signal.
Percent of lymphocyte-gated peripheral blood cells expressing human γc at the cell surface.
¶Mean ± standard error of 2 to 12 available measurements.
#Only one measurement available.