Adverse Events Reported During the Trial Period Possibly or Probably Related to Rituximab or With Unknown Relationship
| . | Arm A (375 mg/m2) . | Arm B (500 mg/m2) . | ||||||
|---|---|---|---|---|---|---|---|---|
| Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | |
| Any adverse event | 35 | 23 | 4 | 1 | 32 | 41 | 12 | 0 |
| General disorders | 13 | 13 | 3 | 1 | 8 | 8 | 4 | 0 |
| Fever | 4 | 8 | — | — | 4 | 5 | 1 | — |
| Rigors | 3 | 4 | 3 | — | — | 4 | 1 | — |
| Hypothermia | 4 | — | — | — | 4 | — | — | — |
| Any pain | 1 | 1 | — | — | — | 1 | 1 | — |
| Oedema | — | — | — | — | — | — | — | — |
| Anaphylactic shock | — | — | — | 1 | — | — | — | — |
| Cardiovascular, mainly hypotension | 5 | 3 | — | — | 1 | 5 | 1 | — |
| Nervous disorders | 3 | 2 | — | — | 2 | 1 | 1 | — |
| Gastrointestinal disorders | 4 | 1 | — | — | 8 | 8 | — | — |
| Respiratory disorders | 6 | 3 | 1 | — | 6 | 3 | — | — |
| Skin (pruritus) | 2 | — | — | — | 3 | 5 | 1 | — |
| Urinary disorders | 1 | 1 | — | — | — | 1 | — | — |
| Thrombocytopenia | — | — | — | — | — | — | 1 | — |
| Anemia | — | — | — | — | — | 1 | 1 | — |
| Neutropenia | — | — | — | — | — | — | 1 | — |
| . | Arm A (375 mg/m2) . | Arm B (500 mg/m2) . | ||||||
|---|---|---|---|---|---|---|---|---|
| Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | |
| Any adverse event | 35 | 23 | 4 | 1 | 32 | 41 | 12 | 0 |
| General disorders | 13 | 13 | 3 | 1 | 8 | 8 | 4 | 0 |
| Fever | 4 | 8 | — | — | 4 | 5 | 1 | — |
| Rigors | 3 | 4 | 3 | — | — | 4 | 1 | — |
| Hypothermia | 4 | — | — | — | 4 | — | — | — |
| Any pain | 1 | 1 | — | — | — | 1 | 1 | — |
| Oedema | — | — | — | — | — | — | — | — |
| Anaphylactic shock | — | — | — | 1 | — | — | — | — |
| Cardiovascular, mainly hypotension | 5 | 3 | — | — | 1 | 5 | 1 | — |
| Nervous disorders | 3 | 2 | — | — | 2 | 1 | 1 | — |
| Gastrointestinal disorders | 4 | 1 | — | — | 8 | 8 | — | — |
| Respiratory disorders | 6 | 3 | 1 | — | 6 | 3 | — | — |
| Skin (pruritus) | 2 | — | — | — | 3 | 5 | 1 | — |
| Urinary disorders | 1 | 1 | — | — | — | 1 | — | — |
| Thrombocytopenia | — | — | — | — | — | — | 1 | — |
| Anemia | — | — | — | — | — | 1 | 1 | — |
| Neutropenia | — | — | — | — | — | — | 1 | — |