Inhibition of IgE Production by RAR-Specific Retinoids in Anti-CD40 + IL-4–Stimulated Human Peripheral B Cells
| . | IgE in pg/mL . |
|---|---|
| Medium | <200 |
| Anti-CD40 + IL-4 | 2951 ± 21 |
| +CD336 | 972 ± 18 |
| +CD2019 | 2321 ± 32 |
| +CD437 | 2291 ± 28 |
| +CD367 | 632 ± 12 |
| . | IgE in pg/mL . |
|---|---|
| Medium | <200 |
| Anti-CD40 + IL-4 | 2951 ± 21 |
| +CD336 | 972 ± 18 |
| +CD2019 | 2321 ± 32 |
| +CD437 | 2291 ± 28 |
| +CD367 | 632 ± 12 |
Peripheral B cells (106/mL) were incubated for 10 days in the presence of CD40 + IL-4 (1 μg/mL and 5 ng/mL) alone or in combination with the different RAR specific retinoids (10−11 mol/L). IgE was detected in the supernatants by ELISA and values are shown as means of triplicates. Shown is one representative of three experiments.