Table 3. Major Peripheral Blood Cell... | American Society of Hematology

Table 3.

Major Peripheral Blood Cell Counts 10 Days After 9 Gy TBI (3 × 3 Gy, 24 Hours Apart) and IP TPO Administration

Time Relative to TBI	TPO Dose (μg)	n	Red Blood Cells (×10¹²/L)	White Blood Cells (×10⁹/L)	Platelets (×10⁹/L)
—	—	9	5.8 ± 0.8	0.26 ± 0.05	51 ± 25
3× + 2h	0.3	6	8.6 ± 0.2^*	0.93 ± 0.23^*	883 ± 163^*
+2h	0.9	3	6.6 ± 0.7	0.43 ± 0.06^*	527 ± 135^*
−2h	0.9	3	7.2 ± 0.2^*	0.47 ± 0.06^*,^†	215 ± 80^*,^†
−2h	30.0	3	8.4 ± 1.0^*	0.90 ± 0.10^*	792 ± 157^*
Normal mice	—	19	10.2 ± 0.6	5.3 ± 1.9	1,123 ± 89

Time Relative to TBI	TPO Dose (μg)	n	Red Blood Cells (×10¹²/L)	White Blood Cells (×10⁹/L)	Platelets (×10⁹/L)
—	—	9	5.8 ± 0.8	0.26 ± 0.05	51 ± 25
3× + 2h	0.3	6	8.6 ± 0.2^*	0.93 ± 0.23^*	883 ± 163^*
+2h	0.9	3	6.6 ± 0.7	0.43 ± 0.06^*	527 ± 135^*
−2h	0.9	3	7.2 ± 0.2^*	0.47 ± 0.06^*,^†	215 ± 80^*,^†
−2h	30.0	3	8.4 ± 1.0^*	0.90 ± 0.10^*	792 ± 157^*
Normal mice	—	19	10.2 ± 0.6	5.3 ± 1.9	1,123 ± 89

3× + 2h, three doses of 0.3 μg TPO 2 hours after each dose of TBI; +2h, 0.9 μg TPO 2 hours after the last dose of TBI; −2h, 0.9 or 30 μg TPO 2 hours before the first dose of TBI.

Significantly different from control mice.

†

Significantly different from mice treated with 30 μg TPO 2 hours before TBI.

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