Table 1.

Major Peripheral Blood Cell Counts 10 Days After 6 Gy TBI and IP TPO Administration

Time Relative to TBI TPO Dose (μg) n Red Blood Cells (×1012/L) White Blood Cells (×109/L) Platelets (×109/L)
—  —  14 7.2 ± 0.5  0.4 ± 0.1  144 ± 62  
+24h  0.3 15  7.5 ± 0.6  0.4 ± 0.1  465 ± 142* 
 +2h 0.3  15  9.0 ± 0.6*-151 1.1 ± 0.4*-151 739 ± 165*-151 
 −2h  0.3  3  9.0 ± 0.2*-151 0.7 ± 0.2*-151 533 ± 55*-152 
 −2h  30.0  9.0 ± 0.3*-151 0.8 ± 0.2*-151 718 ± 86*-151 
Normal mice  —  19  10.2 ± 0.6 5.3 ± 1.9  1,123 ± 89 
Time Relative to TBI TPO Dose (μg) n Red Blood Cells (×1012/L) White Blood Cells (×109/L) Platelets (×109/L)
—  —  14 7.2 ± 0.5  0.4 ± 0.1  144 ± 62  
+24h  0.3 15  7.5 ± 0.6  0.4 ± 0.1  465 ± 142* 
 +2h 0.3  15  9.0 ± 0.6*-151 1.1 ± 0.4*-151 739 ± 165*-151 
 −2h  0.3  3  9.0 ± 0.2*-151 0.7 ± 0.2*-151 533 ± 55*-152 
 −2h  30.0  9.0 ± 0.3*-151 0.8 ± 0.2*-151 718 ± 86*-151 
Normal mice  —  19  10.2 ± 0.6 5.3 ± 1.9  1,123 ± 89 

*Significantly different from control mice.

F0-151

Significantly different from mice treated 24 hours after TBI.

F0-152

Significantly different from mice treated with 30 μg TPO 2 hours before TBI (P = .03).

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