Clinical Characteristics in Relation to CR Rates, DFS, and Overall Survival for 185 Patients With ALL
| Variable . | N (%) . | CR (%) . | P* . | DFS From CR . | Overall Survival . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Median (mos) . | Probability of DFS at 3 yrs (95% CI) . | P4-151 . | Median (mos) . | Probability of Survival at 3 yrs (95% CI) . | P4-151 . | ||||
| Total | 185 | 158 (85) | 23 | 0.40 (0.33-0.48) | 23 | 0.43 (0.36-0.50) | |||
| Age (yrs) | |||||||||
| <30 | 73 (39) | 66 (90) | .17 | 29 | 0.46 (0.34-0.59) | .02 | 47 | 0.57 (0.46-0.68) | <.01 |
| 30-59 | 77 (42) | 65 (84) | 20 | 0.43 (0.32-0.55) | 21 | 0.40 (0.30-0.51) | |||
| ≥60 | 35 (19) | 27 (77) | 11 | 0.19 (0.09-0.35) | 12 | 0.17 (0.09-0.31) | |||
| Gender | |||||||||
| Male | 99 (54) | 90 (91) | .02 | 28 | 0.44 (0.34-0.55) | .14 | 32 | 0.49 (0.40-0.59) | .007 |
| Female | 86 (46) | 68 (79) | 20 | 0.35 (0.25-0.47) | 16 | 0.35 (0.26-0.45) | |||
| Mediastinal mass | |||||||||
| Present | 14 (8) | 13 (93) | .70 | >29 | 0.54 (0.29-0.77) | .38 | >39 | 0.64 (0.39-0.84) | .14 |
| Absent | 168 (92) | 143 (85) | 23 | 0.39 (0.31-0.47) | 23 | 0.41 (0.34-0.49) | |||
| Leukocytes | |||||||||
| <30,000 | 116 (63) | 102 (88) | .28 | 29 | 0.45 (0.35-0.55) | .10 | 31 | 0.48 (0.39-0.57) | .06 |
| ≥30,000 | 69 (37) | 56 (81) | 12 | 0.32 (0.21-0.46) | 15 | 0.33 (0.23-0.45) | |||
| Immunophenotype | |||||||||
| B or BMy | 115 (80) | 98 (85) | 1.00 | 20 | 0.39 (0.30-0.49) | .05 | 18 | 0.40 (0.32-0.49) | .03 |
| T or TMy | 29 (20) | 25 (86) | >34 | 0.60 (0.39-0.77) | >38 | 0.62 (0.43-0.77) | |||
| Cytogenetics | |||||||||
| Ph+ | 26 (30) | 22 (85) | .44 | 13 | 0.18 (0.08-0.36) | .27 | 15 | 0.19 (0.09-0.36) | .10 |
| Ph− | 60 (70) | 55 (92) | 13 | 0.34 (0.23-0.47) | 18 | 0.40 (0.28-0.52) | |||
| Variable . | N (%) . | CR (%) . | P* . | DFS From CR . | Overall Survival . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Median (mos) . | Probability of DFS at 3 yrs (95% CI) . | P4-151 . | Median (mos) . | Probability of Survival at 3 yrs (95% CI) . | P4-151 . | ||||
| Total | 185 | 158 (85) | 23 | 0.40 (0.33-0.48) | 23 | 0.43 (0.36-0.50) | |||
| Age (yrs) | |||||||||
| <30 | 73 (39) | 66 (90) | .17 | 29 | 0.46 (0.34-0.59) | .02 | 47 | 0.57 (0.46-0.68) | <.01 |
| 30-59 | 77 (42) | 65 (84) | 20 | 0.43 (0.32-0.55) | 21 | 0.40 (0.30-0.51) | |||
| ≥60 | 35 (19) | 27 (77) | 11 | 0.19 (0.09-0.35) | 12 | 0.17 (0.09-0.31) | |||
| Gender | |||||||||
| Male | 99 (54) | 90 (91) | .02 | 28 | 0.44 (0.34-0.55) | .14 | 32 | 0.49 (0.40-0.59) | .007 |
| Female | 86 (46) | 68 (79) | 20 | 0.35 (0.25-0.47) | 16 | 0.35 (0.26-0.45) | |||
| Mediastinal mass | |||||||||
| Present | 14 (8) | 13 (93) | .70 | >29 | 0.54 (0.29-0.77) | .38 | >39 | 0.64 (0.39-0.84) | .14 |
| Absent | 168 (92) | 143 (85) | 23 | 0.39 (0.31-0.47) | 23 | 0.41 (0.34-0.49) | |||
| Leukocytes | |||||||||
| <30,000 | 116 (63) | 102 (88) | .28 | 29 | 0.45 (0.35-0.55) | .10 | 31 | 0.48 (0.39-0.57) | .06 |
| ≥30,000 | 69 (37) | 56 (81) | 12 | 0.32 (0.21-0.46) | 15 | 0.33 (0.23-0.45) | |||
| Immunophenotype | |||||||||
| B or BMy | 115 (80) | 98 (85) | 1.00 | 20 | 0.39 (0.30-0.49) | .05 | 18 | 0.40 (0.32-0.49) | .03 |
| T or TMy | 29 (20) | 25 (86) | >34 | 0.60 (0.39-0.77) | >38 | 0.62 (0.43-0.77) | |||
| Cytogenetics | |||||||||
| Ph+ | 26 (30) | 22 (85) | .44 | 13 | 0.18 (0.08-0.36) | .27 | 15 | 0.19 (0.09-0.36) | .10 |
| Ph− | 60 (70) | 55 (92) | 13 | 0.34 (0.23-0.47) | 18 | 0.40 (0.28-0.52) | |||
*Fisher’s exact test.
Log-rank test.