Table 4. Significant Association Between... | American Society of Hematology

Table 4.

Significant Association Between Compatibility of Adhesion Molecules and Acute GVHD in BMT of HLA-Identical Siblings and Their Restriction to HLA Superfamilies

HLA Superfamily^*	Patient No.^3-151	Genotypes Matched for Adhesion Molecules		Acute GVHD Grade ≧1	No GVHD	% GVHD	P Value	P_corrected^3-152	Odds Ratio
A3-like	47	CD62L	IC^3-153	7	0	100	.01	.03	18.2
			C	18	22	45
		CD62L + CD49b	IC	8	0	100	.004	.07	21.8
			C	17	22	44
B44-like	57	CD31 (codons 563/670)^3-155	IC	14	2	88	.003	.018	8.9
			C	18	23	44
		CD31¶ + CD62L	IC	19	4	83	.001	.018	7.7
			C	13	21	38

HLA Superfamily^*	Patient No.^3-151	Genotypes Matched for Adhesion Molecules		Acute GVHD Grade ≧1	No GVHD	% GVHD	P Value	P_corrected^3-152	Odds Ratio
A3-like	47	CD62L	IC^3-153	7	0	100	.01	.03	18.2
			C	18	22	45
		CD62L + CD49b	IC	8	0	100	.004	.07	21.8
			C	17	22	44
B44-like	57	CD31 (codons 563/670)^3-155	IC	14	2	88	.003	.018	8.9
			C	18	23	44
		CD31¶ + CD62L	IC	19	4	83	.001	.018	7.7
			C	13	21	38

*HLA superfamily based on similarities of their peptide-binding motifs, such as HLA-A3-like (A3, A11, A31, A33 and A*6801), B44-like (B37, B41, B44, B45, B47, B49, B50, B60 and B61).29

F3-151

Total number of patients: 118.

F3-152

P_corrected = 1 − (1 − p)ⁿ, where P is the original P value and n is the number of tests performed (n = 3 for CD62L, n = 6 for CD31, n = 18 for CD49b + CD62L and CD31∥ + CD62L).

F3-153

The definition of the compatibility is as follows. If the recipient has no adhesion molecule alleles that are foreign to the donor, the genotypes are considered compatible; if any adhesion molecule alleles found in the recipient are also not found in the donor, the genotypes are considered incompatible.

F3-155

New substitutions not reported by Behar et al.23

¶CD31 codons 563/670.

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