Hematological Parameters and Hematopoietic Progenitor Numbers at 20 Weeks After Completion of a Six-Cycle Administration of Cytotoxic Agents. Effect of G-CSF
| Treatment . | CFU-S Per Hind Limb . | P Value3-150 . | CAFC-28 Per Hind Limb . | P Value3-150,3-151 . | ||
|---|---|---|---|---|---|---|
| No G-CSF . | +G-CSF . | No G-CSF . | +G-CSF . | |||
| Saline | 6,109 ± 440 (15) | 5,679 ± 355 (8) | .46 | 949 (732-1,229) | 1,060 (712-1,229) | NS |
| VP-16 + cisplatinum | 7,588 ± 1,515 (6) | 4,383 ± 462 (8) | .09 | NA | NA | |
| Cyclophosphamide | 6,132 ± 509 (13) | 4,455 ± 488 (8) | .03 | 2,805 (1,916-4,106) | 1,717 (1,165-2,531) | NS |
| Carboplatinum | 4,523 ± 487 (8) | 3,413 ± 366 (8) | .09 | 487 (362-656) | 287 (221-372) | NS |
| Chlorambucil | 5,063 ± 560 (8) | 4,295 ± 437 (8) | .30 | 1,631 (1,273-2,090) | 479 (342-672) | <.001 |
| BCNU | 4,475 ± 218 (10) | 3,432 ± 231 (10) | <.01 | 1,470 (1,001-2,158) | 93 (66-130) | <.001 |
| TBI | 1,905 ± 182 (16) | 937 ± 211 (8) | <.01 | 582 (450-753) | 184 (138-244) | <.001 |
| Treatment . | CFU-S Per Hind Limb . | P Value3-150 . | CAFC-28 Per Hind Limb . | P Value3-150,3-151 . | ||
|---|---|---|---|---|---|---|
| No G-CSF . | +G-CSF . | No G-CSF . | +G-CSF . | |||
| Saline | 6,109 ± 440 (15) | 5,679 ± 355 (8) | .46 | 949 (732-1,229) | 1,060 (712-1,229) | NS |
| VP-16 + cisplatinum | 7,588 ± 1,515 (6) | 4,383 ± 462 (8) | .09 | NA | NA | |
| Cyclophosphamide | 6,132 ± 509 (13) | 4,455 ± 488 (8) | .03 | 2,805 (1,916-4,106) | 1,717 (1,165-2,531) | NS |
| Carboplatinum | 4,523 ± 487 (8) | 3,413 ± 366 (8) | .09 | 487 (362-656) | 287 (221-372) | NS |
| Chlorambucil | 5,063 ± 560 (8) | 4,295 ± 437 (8) | .30 | 1,631 (1,273-2,090) | 479 (342-672) | <.001 |
| BCNU | 4,475 ± 218 (10) | 3,432 ± 231 (10) | <.01 | 1,470 (1,001-2,158) | 93 (66-130) | <.001 |
| TBI | 1,905 ± 182 (16) | 937 ± 211 (8) | <.01 | 582 (450-753) | 184 (138-244) | <.001 |
CFU-S frequencies were determined from pooled marrow from 3 to 5 mice per experiment, the average frequency was calculated from 1 to 3 experiments; total number of CFU-S recipients is given in parentheses. CAFC frequencies were determined from pooled marrow from 3 to 5 mice per experiment, the average frequency was calculated from 1 to 3 experiments with 95% confidence intervals (given in parentheses).
Abbreviations: NA, not available; NS, not significant.
P values are for comparison with drug alone.
P values for CAFC-28 are shown as <.05 (.01 < P < .05), <.01 (.001 < P < .01) or as P < .001.