Hematological Parameters and Hematopoietic Progenitor Numbers at 20 Weeks After Completion of a Six-Cycle Administration of Cytotoxic Agents. Effect of G-CSF
| Treatment . | WBC (×106/mL) . | P Value* . | BMC (×106/HL) . | P Value* . | ||
|---|---|---|---|---|---|---|
| No G-CSF . | + G-CSF . | No G-CSF . | +G-CSF . | |||
| Saline | 10.7 ± 0.5 (5) | 9.7 ± 1.5 (5) | .57 | 51.0 ± 3.5 (5) | 47.1 ± 2.0 (5) | .35 |
| Cyclophosphamide | 9.9 ± 1.4 (5) | 8.0 ± 0.5 (5) | .24 | 47.3 ± 4.3 (5) | 54.2 ± 1.8 (5) | .20 |
| Carboplatinum | 8.7 ± 0.9 (5) | 7.1 ± 1.0 (5) | .28 | 40.6 ± 1.3 (5) | 50.0 ± 2.3 (5) | .01 |
| Chlorambucil | 9.1 ± 0.8 (5) | 9.8 ± 1.3 (5) | .63 | 45.0 ± 2.9 (5) | 51.0 ± 1.0 (5) | .11 |
| BCNU | NA | NA | 33.9 ± 4.9 (3) | 28.6 ± 3.2 (3) | .43 | |
| TBI | 7.0 ± 1.2 (5) | 7.1 ± 1.0 (5) | .92 | 46.4 ± 2.5 (5) | 36.9 ± 3.2 (5) | .05 |
| Treatment . | WBC (×106/mL) . | P Value* . | BMC (×106/HL) . | P Value* . | ||
|---|---|---|---|---|---|---|
| No G-CSF . | + G-CSF . | No G-CSF . | +G-CSF . | |||
| Saline | 10.7 ± 0.5 (5) | 9.7 ± 1.5 (5) | .57 | 51.0 ± 3.5 (5) | 47.1 ± 2.0 (5) | .35 |
| Cyclophosphamide | 9.9 ± 1.4 (5) | 8.0 ± 0.5 (5) | .24 | 47.3 ± 4.3 (5) | 54.2 ± 1.8 (5) | .20 |
| Carboplatinum | 8.7 ± 0.9 (5) | 7.1 ± 1.0 (5) | .28 | 40.6 ± 1.3 (5) | 50.0 ± 2.3 (5) | .01 |
| Chlorambucil | 9.1 ± 0.8 (5) | 9.8 ± 1.3 (5) | .63 | 45.0 ± 2.9 (5) | 51.0 ± 1.0 (5) | .11 |
| BCNU | NA | NA | 33.9 ± 4.9 (3) | 28.6 ± 3.2 (3) | .43 | |
| TBI | 7.0 ± 1.2 (5) | 7.1 ± 1.0 (5) | .92 | 46.4 ± 2.5 (5) | 36.9 ± 3.2 (5) | .05 |
WBC and BMC; n is given in parentheses for individual mice from 1 to 3 separate experiments.
Abbreviation: NA, not available.
P values are for comparison with drug alone.