Patient Demographics
No. of patients | 358 |
Prior therapy | |
None | 179 |
Splenectomy alone | 44 |
Interferon alone | 78 |
Splenectomy, interferon | 47 |
Splenectomy, interferon, 2′-deoxycoformycin | 4 |
Interferon, 2′-deoxycoformycin | 3 |
2′-Deoxycoformycin alone | 1 |
Other regimens | 2 |
Spleen size | |
Splenectomized | 98 |
No splenomegaly | 71 |
Mild (1-2 fingerbreadths) | 50 |
Moderate (3-4 fingerbreadths) | 58 |
Massive (greater than 4 fingerbreadths) | 76 |
Unknown | 5 |
Lymphadenopathy | 109 |
Peripheral blood hematologic parameters | |
Absolute neutrophil count (×109/L) | |
Median (range) | 0.9 (0.1-12.5) |
Hemoglobin level (g/dL) | |
Median (range) | 11.3 (4.6-16.6) |
Platelets (×109/L) | |
Median (range) | 81 (7-575) |
Peripheral blood immunophenotypic profile | |
Typical for hairy cell leukemia (CD11c, CD25, and CD103 all positive) | 174 |
Atypical for hairy cell leukemia (one or more markers negative) | 35 |
Not done | 149 |
Bone marrow infiltration by hairy cells (percentage) | |
Median | 80 |
Range | 1-100 |
No. of patients | 358 |
Prior therapy | |
None | 179 |
Splenectomy alone | 44 |
Interferon alone | 78 |
Splenectomy, interferon | 47 |
Splenectomy, interferon, 2′-deoxycoformycin | 4 |
Interferon, 2′-deoxycoformycin | 3 |
2′-Deoxycoformycin alone | 1 |
Other regimens | 2 |
Spleen size | |
Splenectomized | 98 |
No splenomegaly | 71 |
Mild (1-2 fingerbreadths) | 50 |
Moderate (3-4 fingerbreadths) | 58 |
Massive (greater than 4 fingerbreadths) | 76 |
Unknown | 5 |
Lymphadenopathy | 109 |
Peripheral blood hematologic parameters | |
Absolute neutrophil count (×109/L) | |
Median (range) | 0.9 (0.1-12.5) |
Hemoglobin level (g/dL) | |
Median (range) | 11.3 (4.6-16.6) |
Platelets (×109/L) | |
Median (range) | 81 (7-575) |
Peripheral blood immunophenotypic profile | |
Typical for hairy cell leukemia (CD11c, CD25, and CD103 all positive) | 174 |
Atypical for hairy cell leukemia (one or more markers negative) | 35 |
Not done | 149 |
Bone marrow infiltration by hairy cells (percentage) | |
Median | 80 |
Range | 1-100 |