Dose of IFN- in Cytogenetic Responders and Nonresponders
| Treatment Period (yr) . | IFN-α Weekly Dose (mIU, Total) . | |
|---|---|---|
| Cytogenetic Responders at 14 Months (n = 74) . | Cytogenetic Nonresponders at 14 Months (n = 84) . | |
| 1 | 50.4 ± 15.4 | 36.4 ± 17.5 |
| 2 | 43.4 ± 28.0 | 14.7 ± 11.2 |
| 3 | 30.8 ± 23.1 | 11.2 ± 18.2 |
| 4 | 25.2 ± 21.7 | 5.6 ± 13.3 |
| 5 | 21.0 ± 16.1 | 10.5 ± 19.6 |
| 6 | 19.6 ± 16.1 | — |
| 7 | 19.6 ± 18.2 | — |
| 8 | 22.4 ± 16.8 | — |
| 9 | 20.4 ± 15.4 | — |
| Treatment Period (yr) . | IFN-α Weekly Dose (mIU, Total) . | |
|---|---|---|
| Cytogenetic Responders at 14 Months (n = 74) . | Cytogenetic Nonresponders at 14 Months (n = 84) . | |
| 1 | 50.4 ± 15.4 | 36.4 ± 17.5 |
| 2 | 43.4 ± 28.0 | 14.7 ± 11.2 |
| 3 | 30.8 ± 23.1 | 11.2 ± 18.2 |
| 4 | 25.2 ± 21.7 | 5.6 ± 13.3 |
| 5 | 21.0 ± 16.1 | 10.5 ± 19.6 |
| 6 | 19.6 ± 16.1 | — |
| 7 | 19.6 ± 18.2 | — |
| 8 | 22.4 ± 16.8 | — |
| 9 | 20.4 ± 15.4 | — |
The dose of IFN that was received by the patients who achieved any degree of cytogenetic response was higher (P < .001, Student’s t-test) than the dose of IFN-α that was received by the patients who did not achieve any cytogenetic response during the first 14 months. Subsequently, the dose decreased progressively to about 20 mIU weekly in the responders and to about 10 mIU weekly in the nonresponders. After the 5th year only 5 nonresponder patients were still receiving IFN-α.