Expression of MLL-AF4 Fusion Transcripts in Normal Hematopoietic Tissues
| Tissue . | N . | MLL-AF4+ . | |||
|---|---|---|---|---|---|
| Standard PCR . | Nested PCR . | ||||
| N . | % Total . | N . | % Total . | ||
| Infant BM | 6 | 0 | 0 | 1 | 17 |
| Fetal BM | 16 | 0 | 0 | 4 | 25 |
| Fetal liver | 13 | 0 | 0 | 5 | 38 |
| Pediatric ALL remission BM | 44 | 0 | 0 | 0 | 0 |
| Tissue . | N . | MLL-AF4+ . | |||
|---|---|---|---|---|---|
| Standard PCR . | Nested PCR . | ||||
| N . | % Total . | N . | % Total . | ||
| Infant BM | 6 | 0 | 0 | 1 | 17 |
| Fetal BM | 16 | 0 | 0 | 4 | 25 |
| Fetal liver | 13 | 0 | 0 | 5 | 38 |
| Pediatric ALL remission BM | 44 | 0 | 0 | 0 | 0 |
Infant BM was obtained from an 11-month-old boy.MLL-AF4+ fetal BM were: FBM 4, 19 weeks gestational age; FBM 6, 20 weeks gestational age; FBM 7, 21 weeks gestational age; FBM 11, 18 weeks. MLL-AF4+fetal livers were: FL1, 16 weeks gestational age; FL14, 19 weeks gestational age; FL10, 20 weeks gestational age; FL12, 21 weeks gestational age, FL13, 22 weeks gestational age. Remission BM specimens were day 28 aspirate samples from pediatric ALL patients on CCG-1952 standard-risk ALL study.