Presenting Features and Karyotypes for Children With MLL-AF4+ ALL
| UPN . | Age (yr) . | WBC (×103/μL) . | Karyotype . | Fusion Transcript . | |||
|---|---|---|---|---|---|---|---|
| MLL-AF4 . | E2A-PBX1 . | BCR-ABL . | |||||
| Standard PCR . | Nested PCR . | Standard PCR . | Standard+ Nested PCR . | ||||
| A. t(4;11) (N = 2) | |||||||
| PEDS 87* | 4.7 | 132.0 | 47,XX,+X,t(4;11)(q21;q23),del(17)(p1)/47,XX,t(4;11)(q21;q23),−13,+21,+mar | − | + | − | − |
| PEDS 91 | 17.7 | 247.5 | 46,XY,t(4;11)(q21;q23) | + | + | − | − |
| B. Pseudodiploid non-t(4;11) (N = 3) | |||||||
| PEDS 27 | 15.9 | 218.0 | 46,XY,+10,t(14;15)(q32;q1?5),add(19)(p13.3),−21 | − | + | − | − |
| PEDS 37 | 9 | 19.6 | 46,XX,−21,+mar | − | + | − | − |
| PEDS 79 | 9.8 | 13.3 | 46,XY,−9,+mar | − | + | − | − |
| C. Hyperdiploid non-t(4;11) (N = 6) | |||||||
| PEDS 43* | 4.4 | 3.3 | 47,XY,add(2)(q31),del(6)(q2?3;q25), add(12)(p13),del(14)(q31), −17,+20,+mar | − | + | − | − |
| PEDS 44* | 11.6 | 17.5 | 50,XY,+4,del(5)(q13),+del(6)(q21),−7,+11,+21 | − | + | − | − |
| PEDS 57 | 6.4 | 6.2 | 53,XX,+X,+6,+17,+20,+21,+2mar | − | + | − | − |
| PEDS 58 | 5.4 | 7.0 | 47,XY,del(11)(q23),+12 | − | + | − | − |
| PEDS 59* | 7.3 | 9.7 | 51,XX,+8,+?8,−13,+21,+21,+21,+mar | − | + | − | − |
| PEDS 111* | 3.3 | 2.8 | 55,XY,+X,+4,+8,+8,+10,+14,+17,+18,+21 | − | + | − | − |
| D. Normal diploid (N = 6) | |||||||
| PEDS 5 | 2.9 | 645.3 | 46,XX | − | + | − | − |
| PEDS 66 | 6.8 | ND† | 46,XX | − | + | − | − |
| PEDS 69 | 2.5 | 6.8 | 46,XX | − | + | − | − |
| PEDS 76 | 5.8 | 188.6 | 46,XY | − | + | − | − |
| PEDS 86 | 2.1 | 6.6 | 46,XY | − | + | − | − |
| PEDS 106 | 1.3 | 19.6 | 46,XY | − | + | − | − |
| UPN . | Age (yr) . | WBC (×103/μL) . | Karyotype . | Fusion Transcript . | |||
|---|---|---|---|---|---|---|---|
| MLL-AF4 . | E2A-PBX1 . | BCR-ABL . | |||||
| Standard PCR . | Nested PCR . | Standard PCR . | Standard+ Nested PCR . | ||||
| A. t(4;11) (N = 2) | |||||||
| PEDS 87* | 4.7 | 132.0 | 47,XX,+X,t(4;11)(q21;q23),del(17)(p1)/47,XX,t(4;11)(q21;q23),−13,+21,+mar | − | + | − | − |
| PEDS 91 | 17.7 | 247.5 | 46,XY,t(4;11)(q21;q23) | + | + | − | − |
| B. Pseudodiploid non-t(4;11) (N = 3) | |||||||
| PEDS 27 | 15.9 | 218.0 | 46,XY,+10,t(14;15)(q32;q1?5),add(19)(p13.3),−21 | − | + | − | − |
| PEDS 37 | 9 | 19.6 | 46,XX,−21,+mar | − | + | − | − |
| PEDS 79 | 9.8 | 13.3 | 46,XY,−9,+mar | − | + | − | − |
| C. Hyperdiploid non-t(4;11) (N = 6) | |||||||
| PEDS 43* | 4.4 | 3.3 | 47,XY,add(2)(q31),del(6)(q2?3;q25), add(12)(p13),del(14)(q31), −17,+20,+mar | − | + | − | − |
| PEDS 44* | 11.6 | 17.5 | 50,XY,+4,del(5)(q13),+del(6)(q21),−7,+11,+21 | − | + | − | − |
| PEDS 57 | 6.4 | 6.2 | 53,XX,+X,+6,+17,+20,+21,+2mar | − | + | − | − |
| PEDS 58 | 5.4 | 7.0 | 47,XY,del(11)(q23),+12 | − | + | − | − |
| PEDS 59* | 7.3 | 9.7 | 51,XX,+8,+?8,−13,+21,+21,+21,+mar | − | + | − | − |
| PEDS 111* | 3.3 | 2.8 | 55,XY,+X,+4,+8,+8,+10,+14,+17,+18,+21 | − | + | − | − |
| D. Normal diploid (N = 6) | |||||||
| PEDS 5 | 2.9 | 645.3 | 46,XX | − | + | − | − |
| PEDS 66 | 6.8 | ND† | 46,XX | − | + | − | − |
| PEDS 69 | 2.5 | 6.8 | 46,XX | − | + | − | − |
| PEDS 76 | 5.8 | 188.6 | 46,XY | − | + | − | − |
| PEDS 86 | 2.1 | 6.6 | 46,XY | − | + | − | − |
| PEDS 106 | 1.3 | 19.6 | 46,XY | − | + | − | − |
*Patient did not have constitutional +21.
ND, not determined.