Expression of MLL-AF4 Fusion Transcript in Infants (N = 17) and Children (N = 127) With Cytogenetically Classified Acute Lymphoblastic Leukemia
| Patient Group . | N . | MLL-AF4+ . | |
|---|---|---|---|
| Std. PCR N (%) . | Nested PCR N (%) . | ||
| ;A.1 All infants | 17 | 6 (35) | 9 (53) |
| ;A.2 Cytogenetically distinct subgroups of infants | |||
| t(4;11) | 8 | 6 (75) | 8 (100) |
| Pseudodiploid, non-t(4;11) | 6 | 0 (0) | 0 (0) |
| Normal diploid | 2 | 0 (0) | 1 (50) |
| Hyperdiploid, non-t(4;11) | 1 | 0 (0) | 0 (0) |
| B.1 All children | 127 | 1 (0.8) | 17 (13) |
| B.2 Cytogenetically distinct subgroups of children | |||
| t(4;11) | 2 | 1 (50) | 2 (100) |
| Pseudodiploid, non-t(4;11) | 32 | 0 (0) | 3 (9) |
| Normal diploid | 49 | 0 (0) | 6 (12) |
| Hyperdiploid, non-t(4;11) | 41 | 0 (0) | 6 (15) |
| Hypodiploid, non-t(4;11) | 3 | 0 (0) | 0 (0) |
| Patient Group . | N . | MLL-AF4+ . | |
|---|---|---|---|
| Std. PCR N (%) . | Nested PCR N (%) . | ||
| ;A.1 All infants | 17 | 6 (35) | 9 (53) |
| ;A.2 Cytogenetically distinct subgroups of infants | |||
| t(4;11) | 8 | 6 (75) | 8 (100) |
| Pseudodiploid, non-t(4;11) | 6 | 0 (0) | 0 (0) |
| Normal diploid | 2 | 0 (0) | 1 (50) |
| Hyperdiploid, non-t(4;11) | 1 | 0 (0) | 0 (0) |
| B.1 All children | 127 | 1 (0.8) | 17 (13) |
| B.2 Cytogenetically distinct subgroups of children | |||
| t(4;11) | 2 | 1 (50) | 2 (100) |
| Pseudodiploid, non-t(4;11) | 32 | 0 (0) | 3 (9) |
| Normal diploid | 49 | 0 (0) | 6 (12) |
| Hyperdiploid, non-t(4;11) | 41 | 0 (0) | 6 (15) |
| Hypodiploid, non-t(4;11) | 3 | 0 (0) | 0 (0) |