Table 4.

PML-RAR Features in Relapse APL Cases

Case No. PretreatmentRelapse
P-Rα Type Unusual PML-RARα Features? RARα1/α2-PML Expression P-Rα Changes v Pre-Rx?
1  S  No  −/−  No  
2  S C → T nt 24783-150/3′-UT-region   No  
3  L  No  No  
4  L  No   No  
5  S  No  +/− No  
6  V  PE6 nt 1709 break + 3 nt  +/−  No 
7  S  No   No  
8  S  No  −/−  No 
9  V  PE6 nt 1685 break, major  +/+  T → C nt 2745 (1340)3-150 
  PE6 nts 1576 & 1581, minor   ↑ minor isoforms  
10  S  No  +/+  No  
11  L  No +/−  No  
12  V  PE6 nt 1715 break + 6 nt  +/+ No  
13  S  No  +/+  No  
14  S  No  +/− C → T nt 1955 (970)3-150 
15  V  PE6 nt 1685 break, major −PE6, minor  −/−  P-Rα undetectable  
16  V  PE6 nt 1678 break + 127 nt  +/+  No  
17  S  No  C → G nt 2267 (1282)3-150 
18  L  No  +/−  No 
19  L  No  −/−  No  
20  L  No  No 
Case No. PretreatmentRelapse
P-Rα Type Unusual PML-RARα Features? RARα1/α2-PML Expression P-Rα Changes v Pre-Rx?
1  S  No  −/−  No  
2  S C → T nt 24783-150/3′-UT-region   No  
3  L  No  No  
4  L  No   No  
5  S  No  +/− No  
6  V  PE6 nt 1709 break + 3 nt  +/−  No 
7  S  No   No  
8  S  No  −/−  No 
9  V  PE6 nt 1685 break, major  +/+  T → C nt 2745 (1340)3-150 
  PE6 nts 1576 & 1581, minor   ↑ minor isoforms  
10  S  No  +/+  No  
11  L  No +/−  No  
12  V  PE6 nt 1715 break + 6 nt  +/+ No  
13  S  No  +/+  No  
14  S  No  +/− C → T nt 1955 (970)3-150 
15  V  PE6 nt 1685 break, major −PE6, minor  −/−  P-Rα undetectable  
16  V  PE6 nt 1678 break + 127 nt  +/+  No  
17  S  No  C → G nt 2267 (1282)3-150 
18  L  No  +/−  No 
19  L  No  −/−  No  
20  L  No  No 

Abbreviations: P-Rα, PML-RARα; 3′-UT, 3′-untranslated; PE6, PML exon 6; nt, nucleotide.

F3-150

PML-RARα nucleotide number assignment made with reference to sequence reported by de The et al47; parentheses indicate corresponding nucleotide in RARα1 sequence reported by Giguere et al.48 

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