In Vitro RA-Induced Differentiation Response of Pretreatment and Relapse APL Cells From Relapse APL Cases
| Case No. . | Pretreatment . | Relapse . | ||||
|---|---|---|---|---|---|---|
| NBT Test . | CD11b . | NBT Test . | CD11b . | |||
| 10−8 mol/L . | 10−7 mol/L . | 10−7 mol/L . | 10−8 mol/L . | 10−7 mol/L . | 10−7 mol/L . | |
| 1 | 83 | 88 | 68 | 100 | 99 | 71 |
| 2 | NT | NT | NT | 93 | 89 | NT |
| 3 | NT | NT | NT | NT | NT | NT |
| 4 | 77 | 78 | 67 | NT | NT | NT |
| 5 | 75 | 60 | 81 | 74 | 64 | 72 |
| 6 | 69 | 72 | 85 | 78 | 84 | 20 |
| 7 | 96 | 94 | 37 | 100 | 100 | 21 |
| 8 | 67 | 49 | NT | 52 | 33 | 2 |
| 9 | 10 | 78 | 54 | 1 | 6 | 43 |
| 10 | 99 | 97 | NT | 1 | 5 | NT |
| 11 | 44 | 58 | 67 | 49 | 56 | 56 |
| 12 | 79 | 75 | 51 | 0 | 5 | NT |
| 13 | 96 | 94 | 88 | 69 | 75 | NT |
| 14 | 95 | 96 | 93 | 8 | 4 | NT |
| 15 | 0 | 0 | 3 | 1 | 0 | 22 |
| 16 | 35 | 47 | 99 | 6 | 10 | 9 |
| 17 | 88 | 97 | 75 | 17 | 44 | NT |
| 18 | NT | 98 | NT | 8 | 31 | NT |
| 19 | 33 | 25 | 85 | NT | NT | NT |
| 20 | 13 | 7 | 8 | NT | 1 | NT |
| Case No. . | Pretreatment . | Relapse . | ||||
|---|---|---|---|---|---|---|
| NBT Test . | CD11b . | NBT Test . | CD11b . | |||
| 10−8 mol/L . | 10−7 mol/L . | 10−7 mol/L . | 10−8 mol/L . | 10−7 mol/L . | 10−7 mol/L . | |
| 1 | 83 | 88 | 68 | 100 | 99 | 71 |
| 2 | NT | NT | NT | 93 | 89 | NT |
| 3 | NT | NT | NT | NT | NT | NT |
| 4 | 77 | 78 | 67 | NT | NT | NT |
| 5 | 75 | 60 | 81 | 74 | 64 | 72 |
| 6 | 69 | 72 | 85 | 78 | 84 | 20 |
| 7 | 96 | 94 | 37 | 100 | 100 | 21 |
| 8 | 67 | 49 | NT | 52 | 33 | 2 |
| 9 | 10 | 78 | 54 | 1 | 6 | 43 |
| 10 | 99 | 97 | NT | 1 | 5 | NT |
| 11 | 44 | 58 | 67 | 49 | 56 | 56 |
| 12 | 79 | 75 | 51 | 0 | 5 | NT |
| 13 | 96 | 94 | 88 | 69 | 75 | NT |
| 14 | 95 | 96 | 93 | 8 | 4 | NT |
| 15 | 0 | 0 | 3 | 1 | 0 | 22 |
| 16 | 35 | 47 | 99 | 6 | 10 | 9 |
| 17 | 88 | 97 | 75 | 17 | 44 | NT |
| 18 | NT | 98 | NT | 8 | 31 | NT |
| 19 | 33 | 25 | 85 | NT | NT | NT |
| 20 | 13 | 7 | 8 | NT | 1 | NT |
Numbers represent the net percentage of positive cells, ie, the percentage of positive cells cultured in the presence of ATRA minus the percentage of positive cells cultured in the absence of ATRA, as described in the Materials and Methods.