Results of ABMT in Childhood AML in CR
| Institution . | No. of Patients . | Status at Transplant . | Pretransplant Regimen . | Purging . | Actuarial Incidence of (at months) . | Comment . | Reference . | |
|---|---|---|---|---|---|---|---|---|
| LFS . | Relapse . | |||||||
| CCG 2861 | 58 | CR1 | BU-CY | 4 HC | 51 (36) | 42 | Similar to allo-BMT | 32 |
| Parkville, Australia | 24 | CR1 | HDM | No | 87 (60) | 26 | 50 | |
| Italian registry | 110 | CR1 | All regimens TBI TBI/HDM No TBI | No Yes | 41.4 78.8 85 27.2 (84) | 45 | TBI superior | 65 |
| 48 | CR2 | 41.5 (84) | 44 | All regimens equivalent | ||||
| EBMT-Pediatric | 140 70 | CR1 CR2 | All regimens combined | No | 46 36 (92) | No difference with allo-BMT TBI better for ABMT | 66 | |
| Institution . | No. of Patients . | Status at Transplant . | Pretransplant Regimen . | Purging . | Actuarial Incidence of (at months) . | Comment . | Reference . | |
|---|---|---|---|---|---|---|---|---|
| LFS . | Relapse . | |||||||
| CCG 2861 | 58 | CR1 | BU-CY | 4 HC | 51 (36) | 42 | Similar to allo-BMT | 32 |
| Parkville, Australia | 24 | CR1 | HDM | No | 87 (60) | 26 | 50 | |
| Italian registry | 110 | CR1 | All regimens TBI TBI/HDM No TBI | No Yes | 41.4 78.8 85 27.2 (84) | 45 | TBI superior | 65 |
| 48 | CR2 | 41.5 (84) | 44 | All regimens equivalent | ||||
| EBMT-Pediatric | 140 70 | CR1 CR2 | All regimens combined | No | 46 36 (92) | No difference with allo-BMT TBI better for ABMT | 66 | |
Abbreviations: HDM, high-dose melphalan; 4HC, 4 hydroperoxycyclophosphamide; LFS, leukemia-free survival.