Results of ABMT With Purged Marrow in Adult AML in CR1
| Institution . | No. of Patients . | Pretransplant Regimen . | Method of Purging* . | Actuarial Incidence of (at months) . | Comment . | Reference . | |
|---|---|---|---|---|---|---|---|
| LFS . | Relapse . | ||||||
| Manchester | 26 | LTC | 80 | 22 | |||
| Minneapolis | 44 | CY + FTBI BU-CY4 | 4-HC | 59 (24) | CY + FTBI better in CR2 | 23 | |
| Heidelberg | 22 | CY + FTBI | 4-HC | 61 (50) | 36 | 44 | |
| Parma | 24 21 | CY + TBI CY + TBI | Mafosfamide adjusted (61-146) Mafosfamide constant | 68 (23) 47 (18) | 29 48 | Mafosfamide adjusted on normal CFU-Blast | 25 |
| ECOG (pilot) | 39 | BU-CY4 | 4 HC | 54 (36) | 33 | 26 | |
| San Francisco + Berkeley | 50 | BU + VP16 | 4 HC | 70 (80) | 27 | 27, 28 | |
| Paris Saint-Antoine | 64 | CY + TBI | Mafosfamide adjusted (15-170) | 58 | 25 | Mafosfamide adjusted on normal CFU-GM | 29, 30 |
| Sloan Kettering | 15 | CY + VP16 + HFTBI | 4-HC + VP-16 | 72 (70) | 30 | 31 | |
| Baltimore | 48 | BU-CY4 | 4-HC | 41 (120) | 49 | Poor-risk patients only | 35, 36 |
| Institution . | No. of Patients . | Pretransplant Regimen . | Method of Purging* . | Actuarial Incidence of (at months) . | Comment . | Reference . | |
|---|---|---|---|---|---|---|---|
| LFS . | Relapse . | ||||||
| Manchester | 26 | LTC | 80 | 22 | |||
| Minneapolis | 44 | CY + FTBI BU-CY4 | 4-HC | 59 (24) | CY + FTBI better in CR2 | 23 | |
| Heidelberg | 22 | CY + FTBI | 4-HC | 61 (50) | 36 | 44 | |
| Parma | 24 21 | CY + TBI CY + TBI | Mafosfamide adjusted (61-146) Mafosfamide constant | 68 (23) 47 (18) | 29 48 | Mafosfamide adjusted on normal CFU-Blast | 25 |
| ECOG (pilot) | 39 | BU-CY4 | 4 HC | 54 (36) | 33 | 26 | |
| San Francisco + Berkeley | 50 | BU + VP16 | 4 HC | 70 (80) | 27 | 27, 28 | |
| Paris Saint-Antoine | 64 | CY + TBI | Mafosfamide adjusted (15-170) | 58 | 25 | Mafosfamide adjusted on normal CFU-GM | 29, 30 |
| Sloan Kettering | 15 | CY + VP16 + HFTBI | 4-HC + VP-16 | 72 (70) | 30 | 31 | |
| Baltimore | 48 | BU-CY4 | 4-HC | 41 (120) | 49 | Poor-risk patients only | 35, 36 |
Abbreviations: LTC, long-term culture; 4HC, 4 hydroperoxycyclophosphamide; TBI, total body irradiation; FTBI, fractionated total body irradiation; HFTBI, hyperfractionated total body irradiation.
Dose range for mafosfamide when used at adjusted doses within parentheses.