Expression of P-Selectin Molecule on Endothelial Cells in the Liver
| Treatment Group . | 1 h . | 3 h . | 6 h . | 12 h . | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PV . | PP . | PC . | CV . | PV . | PP . | PC . | CV . | PV . | PP . | PC . | CV . | PV . | PP . | PC . | CV . | |
| Control or saline | − | − | − | − | − | − | − | − | − | − | − | − | ND | ND | ND | ND |
| LPS | + | − | +/− | + | ++ | − | + | + | ++ | + | ++ | ++ | + | − | − | + |
| LPS + Anti–P-selectin Ab | +/− | − | − | − | +/− | − | − | − | + | − | − | +/− | +/− | − | − | − |
| LPS + LMW heparin | + | − | − | +/− | + | − | − | +/− | + | − | +/− | + | +/− | − | − | +/− |
| GdCl3 + LPS | + | − | − | +/− | + | − | +/− | +/− | + | − | + | + | +/− | − | − | − |
| Treatment Group . | 1 h . | 3 h . | 6 h . | 12 h . | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PV . | PP . | PC . | CV . | PV . | PP . | PC . | CV . | PV . | PP . | PC . | CV . | PV . | PP . | PC . | CV . | |
| Control or saline | − | − | − | − | − | − | − | − | − | − | − | − | ND | ND | ND | ND |
| LPS | + | − | +/− | + | ++ | − | + | + | ++ | + | ++ | ++ | + | − | − | + |
| LPS + Anti–P-selectin Ab | +/− | − | − | − | +/− | − | − | − | + | − | − | +/− | +/− | − | − | − |
| LPS + LMW heparin | + | − | − | +/− | + | − | − | +/− | + | − | +/− | + | +/− | − | − | +/− |
| GdCl3 + LPS | + | − | − | +/− | + | − | +/− | +/− | + | − | + | + | +/− | − | − | − |
Three rats per group were examined and three sections per rat were observed.
Abbreviations: PV, interlobular portal veins; PP, periportal area; PC, pericentral area; CV, central veins and sublobular veins; ND, not determined; LPS, lipopolysaccharide; Ab, antibody; LMW, low molecular weight; GdCl3, gadolinium chloride; −, negative; +/−, occasional positive or weakly positive; +, positive; ++, strong positive.