Table 1. Effects of IL-6 and... | American Society of Hematology

Table 1.

Effects of IL-6 and Dexamethasone on Cell-Cycle Distribution

Time	Stimulation	8226		UCLA #1
Time	Stimulation	G₀/G₁	S/G₂ + M	G₀/G₁	S/G₂ + M
48 h	Control	54	46	65	35
	IL-6	62	38	60	40
	Dex	76^-150	24^-150	85^-150	15^-150
	Dex + IL-6	71^-150	29^-150	81^-150	19^-150
72 h	Control	53	47	69	31
	IL-6	47	53	64	36
	Dex	79^-150	21^-150	89^-150	11^-150
	Dex + IL-6	76^-150	24^-150	82^-150	18^-150

Time	Stimulation	8226		UCLA #1
Time	Stimulation	G₀/G₁	S/G₂ + M	G₀/G₁	S/G₂ + M
48 h	Control	54	46	65	35
	IL-6	62	38	60	40
	Dex	76^-150	24^-150	85^-150	15^-150
	Dex + IL-6	71^-150	29^-150	81^-150	19^-150
72 h	Control	53	47	69	31
	IL-6	47	53	64	36
	Dex	79^-150	21^-150	89^-150	11^-150
	Dex + IL-6	76^-150	24^-150	82^-150	18^-150

Cell-cycle analysis performed by hypotonic PI staining of 8226 or UCLA #1 MM cells 48 or 72 hours after culture in media (control), IL-6 (1,000 U/mL), dexamethasone (Dex; 10⁻⁶ mol/L) or Dex + IL-6. Results are percentage of cells in G₀/G₁versus S/G₂ + M, mean of three separate experiments. The standard deviations were all <15% of the mean values.

F0-150

Significantly different from corresponding control (media), P< .05.

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