Transplantation of Marrow Cells Exposed Before Transplantation to Cytosine Deaminase Adenoviral Vector Followed by Posttransplantation In Vivo Exposure to 14 Days of 5-FC
| . | Animal Survival Posttransplantation . |
|---|---|
| XRT alone | 32% (8/25) |
| XRT/FBM | 80% (20/25) |
| XRT/FBM/5-FC | 74% (11/15) |
| XRT/FBM/5-FC/AD | 72% (18/25) |
| . | Animal Survival Posttransplantation . |
|---|---|
| XRT alone | 32% (8/25) |
| XRT/FBM | 80% (20/25) |
| XRT/FBM/5-FC | 74% (11/15) |
| XRT/FBM/5-FC/AD | 72% (18/25) |
Results of engraftment (survival) after transplantation with vector-exposed cells followed by 14 days of posttransplant 5-FC (each dose is sufficient to generate a 2-hour peak level of 500 μmol/L).
Abbreviations: XRT, total body irradiation; FBM, fresh bone marrow without incubation; AD, CD adenoviral vector.