Table 1.

Patient's Clinical Antecedents and Laboratory Parameters During the Observation Period

Date PRP (×10−9L) Aggregation-152 by Ristocetin (0.5 mg/mL)FVIII (% of normal) vWF Ag (% of normal)Ristocetin Cofactor (% of normal)
Amplitude (%) Velocity (%)
1959  Year of birth  
1982 Intrauterine death at 26 wk: multiple placental infarcts 
1983  Intrauterine death at 28 wk: multiple placental infarcts  
1995  Left temporo-occipital CVA preceded by “flu”  
29/3/96  Myocardial infarction, autoimmune hyperthyroidism  
22/4/96  Coronarography negative, ANF negative, thrombophilia negative, start aspirin 160 mg/d 239-150 86  91  115  75  100  
26/4/96 Start aspirin 1,000 mg/d  276-150 58  57  
30/4/96  244-151 59  60  
12/6/96  Recurrence of “flu,” ANF positive, corticosteroids added  481  53  47 
9/7/96  Corticosteroids reduced  375-151 47  58  75  
27/8/96  Corticosteroids stopped, ticlopidine + aspirin 100 mg  385  46  55  
8/10/96   400  32  44  —  50  46  
10/12/96   433  55  55  82  62  55  
3/6/97   443-151 57  66  96  41  55 
Date PRP (×10−9L) Aggregation-152 by Ristocetin (0.5 mg/mL)FVIII (% of normal) vWF Ag (% of normal)Ristocetin Cofactor (% of normal)
Amplitude (%) Velocity (%)
1959  Year of birth  
1982 Intrauterine death at 26 wk: multiple placental infarcts 
1983  Intrauterine death at 28 wk: multiple placental infarcts  
1995  Left temporo-occipital CVA preceded by “flu”  
29/3/96  Myocardial infarction, autoimmune hyperthyroidism  
22/4/96  Coronarography negative, ANF negative, thrombophilia negative, start aspirin 160 mg/d 239-150 86  91  115  75  100  
26/4/96 Start aspirin 1,000 mg/d  276-150 58  57  
30/4/96  244-151 59  60  
12/6/96  Recurrence of “flu,” ANF positive, corticosteroids added  481  53  47 
9/7/96  Corticosteroids reduced  375-151 47  58  75  
27/8/96  Corticosteroids stopped, ticlopidine + aspirin 100 mg  385  46  55  
8/10/96   400  32  44  —  50  46  
10/12/96   433  55  55  82  62  55  
3/6/97   443-151 57  66  96  41  55 

Abbreviations: CVA, cerebrovascular accident; ANF, antinuclear factor.

F0-150

Blood platelets aggregated spontaneously following stirring of PRP.

F0-151

No spontaneous platelet aggregation in stirred PRP.

F0-152

Amplitude and velocity of normal controls <10% each.

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