p16INK4a Gene Alterations and Protein Expression in a Series of 112 NHLs
| Diagnosis (Total Cases) . | Deletions . | Mutational Analysis . | Loss of Expression . | Total* . |
|---|---|---|---|---|
| Chronic lymphocytic leukemia | ||||
| Typical (24) | 0/18 | 1/24 | 0/21 | 1/24 (4%) |
| Richter's syndrome (7) | 2/7 | 0/5 | 1/6 | 2/7 (29%) |
| Hairy cell leukemia (1) | 0/1 | 0/1 | 0/1 | 0/1 |
| Follicular lymphoma | ||||
| Typical (18) | 1/15 | 0/16 | 1/18 | 1/18 (6%) |
| Transformed (9) | 1/9 | 2/8 | 3/8 | 3/9 (33%) |
| Mantle cell lymphoma | ||||
| Typical (21) | 1/21 | 0/20 | 1/19 | 1/21 (5%) |
| Blastoid (7) | 3/7 | 0/4 | 2/6 | 3/7 (43%) |
| Large cell lymphoma (18) | 1/11 | 0/14 | 5/18-151 | 5/18 (28%) |
| Burkitt's lymphoma (1) | 0/1 | 0/1 | 0/1 | 0/1 |
| Lymphoblastic lymphoma (4) | 2/3 | 0/1 | 2/4 | 2/4 (50%) |
| ALCL (2) | 0/2 | 0/2 | 1/2-152 | 1/2 (50%) |
| Total | 11/95 (12%) | 3/96 (3%) | 16/104 (15%) | 19/112 (17%) |
| Diagnosis (Total Cases) . | Deletions . | Mutational Analysis . | Loss of Expression . | Total* . |
|---|---|---|---|---|
| Chronic lymphocytic leukemia | ||||
| Typical (24) | 0/18 | 1/24 | 0/21 | 1/24 (4%) |
| Richter's syndrome (7) | 2/7 | 0/5 | 1/6 | 2/7 (29%) |
| Hairy cell leukemia (1) | 0/1 | 0/1 | 0/1 | 0/1 |
| Follicular lymphoma | ||||
| Typical (18) | 1/15 | 0/16 | 1/18 | 1/18 (6%) |
| Transformed (9) | 1/9 | 2/8 | 3/8 | 3/9 (33%) |
| Mantle cell lymphoma | ||||
| Typical (21) | 1/21 | 0/20 | 1/19 | 1/21 (5%) |
| Blastoid (7) | 3/7 | 0/4 | 2/6 | 3/7 (43%) |
| Large cell lymphoma (18) | 1/11 | 0/14 | 5/18-151 | 5/18 (28%) |
| Burkitt's lymphoma (1) | 0/1 | 0/1 | 0/1 | 0/1 |
| Lymphoblastic lymphoma (4) | 2/3 | 0/1 | 2/4 | 2/4 (50%) |
| ALCL (2) | 0/2 | 0/2 | 1/2-152 | 1/2 (50%) |
| Total | 11/95 (12%) | 3/96 (3%) | 16/104 (15%) | 19/112 (17%) |
*Number of cases with p16 alterations (p16 gene deletions, mutations and/or loss of protein expression)/Number of cases tested.
Four cases with loss of protein expression and germ line configuration of the gene showed hypermethylation of exon 1 (see Results).
This case showed hypermethylation of the gene (see Results).