Production of mpl−/−IL-3−/− Mice
| Genotype . | No. of Mice . | |
|---|---|---|
| Observed* . | Expected4-151 . | |
| mpl+/+IL-3+/+ | 15 | 17 |
| mpl+/+IL-3+/− | 44 | 34 |
| mpl+/+IL-3−/− | 14 | 17 |
| mpl+/− IL-3+/+ | 35 | 34 |
| mpl+/− IL-3+/− | 74 | 69 |
| mpl+/− IL-3−/− | 28 | 34 |
| mpl−/− IL-3+/+ | 17 | 17 |
| mpl−/− IL-3+/− | 40 | 34 |
| mpl−/−IL-3−/− | 11 | 17 |
| Genotype . | No. of Mice . | |
|---|---|---|
| Observed* . | Expected4-151 . | |
| mpl+/+IL-3+/+ | 15 | 17 |
| mpl+/+IL-3+/− | 44 | 34 |
| mpl+/+IL-3−/− | 14 | 17 |
| mpl+/− IL-3+/+ | 35 | 34 |
| mpl+/− IL-3+/− | 74 | 69 |
| mpl+/− IL-3−/− | 28 | 34 |
| mpl−/− IL-3+/+ | 17 | 17 |
| mpl−/− IL-3+/− | 40 | 34 |
| mpl−/−IL-3−/− | 11 | 17 |
*Genotypes of 276 offspring from matings betweenmpl+/− IL-3+/− parents.
Expected Mendelian frequency from 276 offspring assuming 1:2:1 ratio for production of wild-type (+/+): heterozygous (+/−): homozygous mutant (−/−) mice. χ2 analysis showed no significant different from observed frequencies (P = .4).