Integrin Tail-Binding Proteins
| Protein . | Integrin Tail Partner . | Notable Features . | Reference . |
|---|---|---|---|
| Calreticulin | α* | Expression correlates with integrin-mediated cell adhesion; present in many subcellular locations. | 173-176 |
| F-actin | α2 only | Structural cytoskeletal protein | 177 |
| Calcium- and integrin-binding protein (CIB) | αIIb only | Sequence homology to calcineurin B; contains 2 EF-hand motifs | 178 |
| Talin | αIIb; β | Structural cytoskeletal protein | 179, 180 |
| α-Actinin | β | Structural cytoskeletal protein | 181 |
| Skelemin | β | A myosin and intermediate filament-associated protein | 182 |
| pp125FAK (focal adhesion kinase) | β | Protein tyrosine kinase localized to focal adhesions | 183 |
| p59ILK (integrin-linked kinase) | β | Contains ankyrin repeats and serine threonine kinase domain; overexpression inhibits cell adhesion and induces anchorage-independent growth | 184 |
| Paxillin | β1 | Adapter with SH2 and SH3 binding motifs and LIM domains | 185 |
| ICAP-1 | β1 only | Cell adhesion via β1 modulates phosphorylation state of ICAP-1 | 186 |
| Filamin | β2 | Structural cytoskeletal protein | 187 |
| Cytohesin-1 | β2 only | Contains Sec7 and PH domains; guanine nucleotide exchange activity for ADP-ribosylation factor; overexpression increases αLβ2-mediated adhesion | 121, 123 |
| β3-endonexin | β3 only | Overexpression increases αIIbβ3affinity and adhesive function | 118, 120 |
| p27BBP | β4 | May link β4 to the intermediate filament cytoskeleton in epithelial cells | 188 |
| Rack 1 | β1; β2; β5 | Binds to the β tails via its 5-7th WD repeats in response to cell stimulation with phorbol ester | 202 |
| Protein . | Integrin Tail Partner . | Notable Features . | Reference . |
|---|---|---|---|
| Calreticulin | α* | Expression correlates with integrin-mediated cell adhesion; present in many subcellular locations. | 173-176 |
| F-actin | α2 only | Structural cytoskeletal protein | 177 |
| Calcium- and integrin-binding protein (CIB) | αIIb only | Sequence homology to calcineurin B; contains 2 EF-hand motifs | 178 |
| Talin | αIIb; β | Structural cytoskeletal protein | 179, 180 |
| α-Actinin | β | Structural cytoskeletal protein | 181 |
| Skelemin | β | A myosin and intermediate filament-associated protein | 182 |
| pp125FAK (focal adhesion kinase) | β | Protein tyrosine kinase localized to focal adhesions | 183 |
| p59ILK (integrin-linked kinase) | β | Contains ankyrin repeats and serine threonine kinase domain; overexpression inhibits cell adhesion and induces anchorage-independent growth | 184 |
| Paxillin | β1 | Adapter with SH2 and SH3 binding motifs and LIM domains | 185 |
| ICAP-1 | β1 only | Cell adhesion via β1 modulates phosphorylation state of ICAP-1 | 186 |
| Filamin | β2 | Structural cytoskeletal protein | 187 |
| Cytohesin-1 | β2 only | Contains Sec7 and PH domains; guanine nucleotide exchange activity for ADP-ribosylation factor; overexpression increases αLβ2-mediated adhesion | 121, 123 |
| β3-endonexin | β3 only | Overexpression increases αIIbβ3affinity and adhesive function | 118, 120 |
| p27BBP | β4 | May link β4 to the intermediate filament cytoskeleton in epithelial cells | 188 |
| Rack 1 | β1; β2; β5 | Binds to the β tails via its 5-7th WD repeats in response to cell stimulation with phorbol ester | 202 |
*Unless specified otherwise, the integrin-binding protein has been shown to bind to more than type of α or β subunit.
Adapted and reprinted with permission.189 Reproduced from The Journal of Clinical Investigation, 1997, Vol. 100, pp. 1, by copyright permission of The American Society for Clinical Investigation.