Table 3.

Summary of Clinical Features of Patients With WT1 Mutations

Sample Age Diagnosis Cytogenetics Achieved CRClinical Summary
 58* 33  AML M1  No clone  No Died of refractory disease  
 87  35  Relapsed AML M0 47 XX +19  —  Died of toxicity  
216* 22 AML M2  No clone  No  Died of refractory disease 
232M* 18  AML M3  Failed  —  Died of cerebral hemorrhage, d 8  
146  17  AML M3  47 XY t(15:17) +8, −21  Yes  Died of disease after second relapse  
126   6  T-ALL  Normal  Yes  Relapsed 21 months after diagnosis, still on treatment  
132* 25 Biphenotypic  Complex >80  No  Died of refractory disease  
101  12  AUL  del (6)(q2), del (11)(p1), add (11)(p1)  ?No  Died of disease 1 year after diagnosis 
Sample Age Diagnosis Cytogenetics Achieved CRClinical Summary
 58* 33  AML M1  No clone  No Died of refractory disease  
 87  35  Relapsed AML M0 47 XX +19  —  Died of toxicity  
216* 22 AML M2  No clone  No  Died of refractory disease 
232M* 18  AML M3  Failed  —  Died of cerebral hemorrhage, d 8  
146  17  AML M3  47 XY t(15:17) +8, −21  Yes  Died of disease after second relapse  
126   6  T-ALL  Normal  Yes  Relapsed 21 months after diagnosis, still on treatment  
132* 25 Biphenotypic  Complex >80  No  Died of refractory disease  
101  12  AUL  del (6)(q2), del (11)(p1), add (11)(p1)  ?No  Died of disease 1 year after diagnosis 

*See King-Underwood et al5 for further details.

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