Table 2. WT1 Mutations in Leukemia... | American Society of Hematology

Table 2.

WT1 Mutations in Leukemia

Mutation	Exon		Sample	Expression	Reference No.
Frameshifts
Insertion 10 bp after Ala¹⁴⁴	Exon 1	Heterozygous	87	—	This study
Insertion 1 bp after Ser¹²¹	Exon 1	Compound heterozygous	58	Expressed	5
Duplication 4 bp after Ser³¹³	Exon 7	Compound heterozygous	58	Unknown	5
Insertion 5 bp after Val³⁰⁰	Exon 7	Heterozygous	132	Mutant allele only	5
Insertion 1 bp after Arg³⁰²	Exon 7	Heterozygous	126	—	This study
Insertion 4 bp after Arg³⁰²	Exon 7	Heterozygous	216	Complex	5
Nonsense
C → T Arg³⁹⁰ → Stop	Exon 9	Heterozygous	232M	Both alleles	5
Missense
T → C Cys²⁸² → Arg	Exon 6	Heterozygous	146	Both alleles	This study
C → T Arg³⁹⁴ → Trp	Exon 9	Heterozygous	101	Mutant allele only	This study

Mutation	Exon		Sample	Expression	Reference No.
Frameshifts
Insertion 10 bp after Ala¹⁴⁴	Exon 1	Heterozygous	87	—	This study
Insertion 1 bp after Ser¹²¹	Exon 1	Compound heterozygous	58	Expressed	5
Duplication 4 bp after Ser³¹³	Exon 7	Compound heterozygous	58	Unknown	5
Insertion 5 bp after Val³⁰⁰	Exon 7	Heterozygous	132	Mutant allele only	5
Insertion 1 bp after Arg³⁰²	Exon 7	Heterozygous	126	—	This study
Insertion 4 bp after Arg³⁰²	Exon 7	Heterozygous	216	Complex	5
Nonsense
C → T Arg³⁹⁰ → Stop	Exon 9	Heterozygous	232M	Both alleles	5
Missense
T → C Cys²⁸² → Arg	Exon 6	Heterozygous	146	Both alleles	This study
C → T Arg³⁹⁴ → Trp	Exon 9	Heterozygous	101	Mutant allele only	This study