Treatment Status, Percentage of Plasma Cells in Bone Marrow, and G-Banded and CGH Karyotypes of Tumor Samples Studied
| Tumor No. . | % Plasma Cells in Bone Marrow . | G-Banded Karyotype . | Loss and Gain Karyotype . |
|---|---|---|---|
| MM untreated | |||
| 02 | 81 | 50-52,+5,del(6)(q15q23),+9,+11×2,+15, −16,+17,+19,−20[cp10]/46,XY[5] | +5,−6q21-qter,+9,+11,+15q23-qter,−16q,+19,−20q |
| 03 | 30 | 76-79,XXX,+1,+3,+6,del(7)(p15),+9, del(9)(p13), del(9)(q22), +10,+11, del(11)(q23),−13,−14, −15,−17,+18,+19,−20,del(20)(q11.2), del(22)(q11.2)[cp5]/46,XX[13] | +5p15,−11q21-qter,−13q21-qter,+19p |
| 04 | 35 | 46,XY | +19 |
| 05 | 31 | 46,XY | +1p21-31,+4,+5q21,+6q,+8q21-24,+11q21-23, +13q21-qter,+18q |
| 06 | 54 | 46,XX,del(12)(p13)[5]/46,XX [20] | −1p31-pter,+3,−4q,−13q11-14,−17p |
| 11 | 63 | 46,XY | None |
| 12 | 30 | 46,XY | None |
| 16 | 98 | 46,XX,del(16)(q22)[27]/46,XX [13] | +9,−13 |
| 18 | 60 | 46,XX | −6q21,+9q,+11q13,−13q21-22,+15,+19 |
| 21 | 2 | 46,XX | None |
| 22 | 47 | 44,XY,−16,−17[5]/46,XY[15] | +1p36,+12q24,−16q11-22,+17q,+19p,−Y |
| 25 | 3 | 46,XX | None |
| 26 | 74 | 46,XY,der(14)t(11;14)(q13;q32)[25] | +11q13-qter,−16q |
| 27 | 80 | 45,X,−Y[3]/46,XY[21] | +12q24,−13q14-32,+17,−18,+19,+22,−Y |
| 28 | 20 | 46,XY | +12q24,+22q11-qter,−Y |
| 29 | 15 | 46,XX | None |
| 30 | 16 | 46,XY,del(11)(q23),der(14)t(11;14)(q13;q32)[7]/46,XY[13] | +11q13-21 |
| MM treated | |||
| 01 | 85 | 81-83,X,−X×3,der(14)t(11;14)(q13;q32),inc[cp10] | +4p,+6p,+11q23,−13,+15q24-qter,−16q,−17p, +17q21 |
| 07 | 90 | 45,X,−X[5]/46,XX[23] | +19 |
| 08 | 62 | 46,XX | +1p31-pter,+1q21,−6q12-21,+16p,+17,+19,+22 |
| 10 | 80 | 46,XX | None |
| 14 | 98 | 46,XX | −3,−13q22 |
| 17 | 90 | 46,XX,add(4)(p15),del(10)(q22),der(14)t(14;7?) (q32;q?)[25] | −4p,+7q31-qter,−8p |
| 19 | 90 | 46-47,XY,del(1)(q21),add(14)(q32),inc[32] | +1q24-25,+8q24,+11q13-14,−13q21-qter,−16q22-23 |
| 24 | 51 | 46,XY | None |
| MGUS | |||
| 09 | 47,XX,+mar[7]/46,XX[22] | −1,−2,−4p,−5p15,−9p23-pter,−13q14-qter,+19 | |
| 13 | 46,XX | None | |
| 15 | 46,XX | −4q23-28,−6q23 | |
| 20 | 46,XX | None | |
| WM | |||
| 23 | 46,XY | −4q33-qter |
| Tumor No. . | % Plasma Cells in Bone Marrow . | G-Banded Karyotype . | Loss and Gain Karyotype . |
|---|---|---|---|
| MM untreated | |||
| 02 | 81 | 50-52,+5,del(6)(q15q23),+9,+11×2,+15, −16,+17,+19,−20[cp10]/46,XY[5] | +5,−6q21-qter,+9,+11,+15q23-qter,−16q,+19,−20q |
| 03 | 30 | 76-79,XXX,+1,+3,+6,del(7)(p15),+9, del(9)(p13), del(9)(q22), +10,+11, del(11)(q23),−13,−14, −15,−17,+18,+19,−20,del(20)(q11.2), del(22)(q11.2)[cp5]/46,XX[13] | +5p15,−11q21-qter,−13q21-qter,+19p |
| 04 | 35 | 46,XY | +19 |
| 05 | 31 | 46,XY | +1p21-31,+4,+5q21,+6q,+8q21-24,+11q21-23, +13q21-qter,+18q |
| 06 | 54 | 46,XX,del(12)(p13)[5]/46,XX [20] | −1p31-pter,+3,−4q,−13q11-14,−17p |
| 11 | 63 | 46,XY | None |
| 12 | 30 | 46,XY | None |
| 16 | 98 | 46,XX,del(16)(q22)[27]/46,XX [13] | +9,−13 |
| 18 | 60 | 46,XX | −6q21,+9q,+11q13,−13q21-22,+15,+19 |
| 21 | 2 | 46,XX | None |
| 22 | 47 | 44,XY,−16,−17[5]/46,XY[15] | +1p36,+12q24,−16q11-22,+17q,+19p,−Y |
| 25 | 3 | 46,XX | None |
| 26 | 74 | 46,XY,der(14)t(11;14)(q13;q32)[25] | +11q13-qter,−16q |
| 27 | 80 | 45,X,−Y[3]/46,XY[21] | +12q24,−13q14-32,+17,−18,+19,+22,−Y |
| 28 | 20 | 46,XY | +12q24,+22q11-qter,−Y |
| 29 | 15 | 46,XX | None |
| 30 | 16 | 46,XY,del(11)(q23),der(14)t(11;14)(q13;q32)[7]/46,XY[13] | +11q13-21 |
| MM treated | |||
| 01 | 85 | 81-83,X,−X×3,der(14)t(11;14)(q13;q32),inc[cp10] | +4p,+6p,+11q23,−13,+15q24-qter,−16q,−17p, +17q21 |
| 07 | 90 | 45,X,−X[5]/46,XX[23] | +19 |
| 08 | 62 | 46,XX | +1p31-pter,+1q21,−6q12-21,+16p,+17,+19,+22 |
| 10 | 80 | 46,XX | None |
| 14 | 98 | 46,XX | −3,−13q22 |
| 17 | 90 | 46,XX,add(4)(p15),del(10)(q22),der(14)t(14;7?) (q32;q?)[25] | −4p,+7q31-qter,−8p |
| 19 | 90 | 46-47,XY,del(1)(q21),add(14)(q32),inc[32] | +1q24-25,+8q24,+11q13-14,−13q21-qter,−16q22-23 |
| 24 | 51 | 46,XY | None |
| MGUS | |||
| 09 | 47,XX,+mar[7]/46,XX[22] | −1,−2,−4p,−5p15,−9p23-pter,−13q14-qter,+19 | |
| 13 | 46,XX | None | |
| 15 | 46,XX | −4q23-28,−6q23 | |
| 20 | 46,XX | None | |
| WM | |||
| 23 | 46,XY | −4q33-qter |