Time to Neutrophil Recovery, Neutropenia-Related Infectious Complications, and Transfusion Support, According to Treatment Group
| Variable . | GM-CSF Group (N = 110) . | Placebo Group (N = 122) . | P Value . |
|---|---|---|---|
| Median time to neutrophil recovery with a neutrophil count >500/μL (days) | 24 | 29 | .00013-151 |
| Median duration of febrile episodes >38.5°C (days) | 8 | 10 | .50* |
| No. of patients with documented infection(s) (%) | 74 (67) | 88 (72) | .423-152 |
| No. of infectious events (%) | |||
| Septicemia | 24 (22) | 34 (28) | .983-152 |
| Pulmonary infection | 27 (25) | 34 (28) | |
| Other documented infection | 31 (28) | 40 (33) | |
| Serious fungal infection | 11 (10) | 13 (11) | |
| Median duration of intravenous antibiotic treatment (days) | 23 | 25 | .018* |
| Median duration of antifungal treatment (days) | 11 | 12 | .90* |
| Median no. of platelet transfusions per patient | 5 | 5 | .67* |
| Median no. of red blood cell transfusions per patient | 9 | 11 | .10* |
| Median duration of hospitalization (days) | 30 | 33 | .10* |
| Variable . | GM-CSF Group (N = 110) . | Placebo Group (N = 122) . | P Value . |
|---|---|---|---|
| Median time to neutrophil recovery with a neutrophil count >500/μL (days) | 24 | 29 | .00013-151 |
| Median duration of febrile episodes >38.5°C (days) | 8 | 10 | .50* |
| No. of patients with documented infection(s) (%) | 74 (67) | 88 (72) | .423-152 |
| No. of infectious events (%) | |||
| Septicemia | 24 (22) | 34 (28) | .983-152 |
| Pulmonary infection | 27 (25) | 34 (28) | |
| Other documented infection | 31 (28) | 40 (33) | |
| Serious fungal infection | 11 (10) | 13 (11) | |
| Median duration of intravenous antibiotic treatment (days) | 23 | 25 | .018* |
| Median duration of antifungal treatment (days) | 11 | 12 | .90* |
| Median no. of platelet transfusions per patient | 5 | 5 | .67* |
| Median no. of red blood cell transfusions per patient | 9 | 11 | .10* |
| Median duration of hospitalization (days) | 30 | 33 | .10* |