DFS According to Treatment Group and Prognostic Factors
| Prognostic Factor (no. of patients who achieved CR) . | Probability of DFS at 2 Years (%) . | ||||
|---|---|---|---|---|---|
| GM-CSF Group . | Placebo Group . | P Value* . | Overall Group . | P Value† . | |
| Age group (yr) | |||||
| 55-64 (n = 62) | 57 | 20 | .002 | 39 | .12 |
| 65-75 (n = 81) | 39 | 21 | .22 | 29 | |
| FAB classification | |||||
| M1-M2-M3 (n = 86) | 54 | 22 | .013 | 37 | .31 |
| Other subtype (n = 57) | 39 | 19 | .11 | 29 | |
| Initial white blood cell count | |||||
| <30,000/μL (n = 117) | 49 | 20 | .012 | 35 | .21 |
| >30,000/μL (n = 26) | 32 | 20 | .21 | 25 | |
| Cytogenetic data | |||||
| Missing (n = 45) | 42 | 16 | .01 | 26 | .36 |
| Favorable or normal (n = 71) | 47 | 25 | .18 | 36 | |
| Intermediate or unfavorable (n = 27) | 57 | 25 | .18 | 41 | |
| Postremission assigned treatment in the 55- to 64-year age subgroup | |||||
| Consolidation + maintenance (n = 23) | 67 | 25 | .031 | 44 | .27 |
| Maintenance treatment only (n = 25) | 57 | 0 | .0002 | 33 | |
| Prognostic Factor (no. of patients who achieved CR) . | Probability of DFS at 2 Years (%) . | ||||
|---|---|---|---|---|---|
| GM-CSF Group . | Placebo Group . | P Value* . | Overall Group . | P Value† . | |
| Age group (yr) | |||||
| 55-64 (n = 62) | 57 | 20 | .002 | 39 | .12 |
| 65-75 (n = 81) | 39 | 21 | .22 | 29 | |
| FAB classification | |||||
| M1-M2-M3 (n = 86) | 54 | 22 | .013 | 37 | .31 |
| Other subtype (n = 57) | 39 | 19 | .11 | 29 | |
| Initial white blood cell count | |||||
| <30,000/μL (n = 117) | 49 | 20 | .012 | 35 | .21 |
| >30,000/μL (n = 26) | 32 | 20 | .21 | 25 | |
| Cytogenetic data | |||||
| Missing (n = 45) | 42 | 16 | .01 | 26 | .36 |
| Favorable or normal (n = 71) | 47 | 25 | .18 | 36 | |
| Intermediate or unfavorable (n = 27) | 57 | 25 | .18 | 41 | |
| Postremission assigned treatment in the 55- to 64-year age subgroup | |||||
| Consolidation + maintenance (n = 23) | 67 | 25 | .031 | 44 | .27 |
| Maintenance treatment only (n = 25) | 57 | 0 | .0002 | 33 | |
*Log-rank test for DFS by treatment group for each prognostic factor strata.
Log-rank test for DFS by prognostic factors.