Summary of Mutation Analysis
| Cell Line . | Lineage . | Origin . | SSCP . | Sequence . | Protein . |
|---|---|---|---|---|---|
| KM3 | B | B-ALL | Mutation | del (g114-12)-150 | − |
| Daudi | B | BL | Mutation | G108V | + |
| Raji | B | BL | wt | wt | ND |
| Ramos | B | BL | wt | wt | ND |
| Rpmi6666 | B | HD | wt | wt | ND |
| SUDHL6 | B | FL | wt | wt | + |
| UM1 | B | MM | wt | wt | ND |
| U266 | B | MM | wt | wt | ND |
| Rpmi8226 | B | MM | wt | wt | ND |
| IM-9 | B | MM | wt | wt | ND |
| FRAVEL | B | MM | wt | wt | ND |
| OPM1 | B | PC | Mutation | G11E | + |
| HS-sultan | B | PC | wt | wt | ND |
| MC-CAR | B | PC | wt | wt | ND |
| ARH77 | B | PCL | wt | wt | ND |
| CEM | T | T-ALL | Mutation | del (g114-121)-150 | + |
| Jurkat | T | T-ALL | 2 mutations | del/ins (g114-121)-151 | − |
| JM-150 | T | T-ALL | 2 mutations | del/ins (g114-121)-152 | − |
| HPB-ALL | T | T-ALL | Mutation | G67R | + |
| GH1 | T | T-ALL | wt | wt | ND |
| PEER | T | T-ALL | wt | wt | ND |
| HSB2 | T | T-ALL | wt | wt | ND |
| MOLT4 | T | T-ALL | wt | wt | ND |
| KCL22 | M | CML | wt | wt | ND |
| KYO | M | CML | wt | wt | ND |
| K562 | M | CML-E | wt | wt | + |
| BV173 | M | CML-L | wt | wt | + |
| HL60 | M | APL | wt | wt | ND |
| Kazumi | M | AML-M2 | wt | wt | ND |
| Cell Line . | Lineage . | Origin . | SSCP . | Sequence . | Protein . |
|---|---|---|---|---|---|
| KM3 | B | B-ALL | Mutation | del (g114-12)-150 | − |
| Daudi | B | BL | Mutation | G108V | + |
| Raji | B | BL | wt | wt | ND |
| Ramos | B | BL | wt | wt | ND |
| Rpmi6666 | B | HD | wt | wt | ND |
| SUDHL6 | B | FL | wt | wt | + |
| UM1 | B | MM | wt | wt | ND |
| U266 | B | MM | wt | wt | ND |
| Rpmi8226 | B | MM | wt | wt | ND |
| IM-9 | B | MM | wt | wt | ND |
| FRAVEL | B | MM | wt | wt | ND |
| OPM1 | B | PC | Mutation | G11E | + |
| HS-sultan | B | PC | wt | wt | ND |
| MC-CAR | B | PC | wt | wt | ND |
| ARH77 | B | PCL | wt | wt | ND |
| CEM | T | T-ALL | Mutation | del (g114-121)-150 | + |
| Jurkat | T | T-ALL | 2 mutations | del/ins (g114-121)-151 | − |
| JM-150 | T | T-ALL | 2 mutations | del/ins (g114-121)-152 | − |
| HPB-ALL | T | T-ALL | Mutation | G67R | + |
| GH1 | T | T-ALL | wt | wt | ND |
| PEER | T | T-ALL | wt | wt | ND |
| HSB2 | T | T-ALL | wt | wt | ND |
| MOLT4 | T | T-ALL | wt | wt | ND |
| KCL22 | M | CML | wt | wt | ND |
| KYO | M | CML | wt | wt | ND |
| K562 | M | CML-E | wt | wt | + |
| BV173 | M | CML-L | wt | wt | + |
| HL60 | M | APL | wt | wt | ND |
| Kazumi | M | AML-M2 | wt | wt | ND |
The presence of mutations in cell lines of hematopoietic malignancies as determined by SSCP and sequence analysis.
Abbreviations: BL, Burkitt's lymphoma; B-ALL, B-cell acute lymphoblastic leukemia; HD, Hodgkin's disease; FL, follicular lymphoma; MM, multiple myeloma; PC, plasmacytoma; PCL, plasma cell leukemia; T-ALL, T-cell acute lymphoblastic leukemia; CML, chronic myeloid leukemia; CML-E, CML with blast crisis of erythroid lineage; CML-L, CML with blast crisis of lymphoid lineage; APL, acute promyelocytic leukemia; AML-M2, acute myeloid leukemia of M2 subtype.
Deletion of 1 guanine residue in guanine stretch (nt114-121).
JM derived from Jurkat line.
Deletion of 1 guanine stretch (nt114-121) on first allele and insertion of 1 guanine residue in guanine stretch (nt114-121) on second allele. Results are based on at least two independent SSCP or DNA sequence analyses.