Table 3.

EC Killing in an Indirect Immunotoxin Assay by NKI-P1 anti-CD44 Antibody

Experiment 1Experiment 2Experiment 3
 EC HaCaT 
     
Control Ab (OKT3/CD3) 2,953* ± 143 1,328 ± 340 980 ± 105 3,295 ± 384 
Anti-CD44 (NKI-P1) 1,717 ± 201 617 ± 80 759 ± 54 1,894 ± 171 
Cycloheximide 200 279 ± 78 41 ± 4 176 ± 25 
Inhibition of protein synthesis 45%3-151 68% 34% 45% 
By NKI-P1 anti-CD44     
Experiment 1Experiment 2Experiment 3
 EC HaCaT 
     
Control Ab (OKT3/CD3) 2,953* ± 143 1,328 ± 340 980 ± 105 3,295 ± 384 
Anti-CD44 (NKI-P1) 1,717 ± 201 617 ± 80 759 ± 54 1,894 ± 171 
Cycloheximide 200 279 ± 78 41 ± 4 176 ± 25 
Inhibition of protein synthesis 45%3-151 68% 34% 45% 
By NKI-P1 anti-CD44     
F3-150

Protein synthesis measured in counts per minute after incorporation of 3H-leucine.

F3-151

Percentage of control Ab values after subtraction of cycloheximide values.

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