Table 4.

Effect of NAC on In Vitro Formation of ISCs and β-Actin Thiols

Experiment No. Δ ISCs % Δ Actin Thiols %
−29.9  +46.5  
2  −18.4  +22.4  
3  −37.5 +12.0  
4  −45.2  +11.7  
Mean  −32.8 ± 5.73-150 +23.1 ± 8.23-150 
Experiment No. Δ ISCs % Δ Actin Thiols %
−29.9  +46.5  
2  −18.4  +22.4  
3  −37.5 +12.0  
4  −45.2  +11.7  
Mean  −32.8 ± 5.73-150 +23.1 ± 8.23-150 

The data represent the change in ISCs and β-actin available thiols in sickle cells which have been oxygenation-deoxygenation cycled for 16 hours in the presence of 0 or 20 mmol/L, NAC. Mean values are given ± standard error. The four experiments represent four independent homozygous SS subjects.

F3-150

Indicates a significant difference (P < .05).

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