Table 4. Inflammatory Lesions and Liver... | American Society of Hematology

Table 4.

Inflammatory Lesions and Liver Fibrosis

Parameter	Before Phlebotomy	Last Follow-up	Two-tailed P Value
AST (times upper level)	2.7 ± 2	1.1 ± 0.6	<.0001^4-150
ALT (times upper level)	5.2 ± 3.4	1.7 ± 1.2	<.0001^4-150
Liver histology scores⁷:
Piecemeal Necrosis	1 (0-1)	0 (0-1)	.0126^4-151
Intralobular degeneration	1 (1-3)	0 (0-1)	.0001^4-151
Portal inflammation	1 (1-3)	1 (1-1)	.0063^4-151
Fibrosis	3 (3-3)	3 (1-3)	.18^4-151
Knodell index^‡	6.9 ± 3	4.9 ± 2.8	<.0001^4-150

Parameter	Before Phlebotomy	Last Follow-up	Two-tailed P Value
AST (times upper level)	2.7 ± 2	1.1 ± 0.6	<.0001^4-150
ALT (times upper level)	5.2 ± 3.4	1.7 ± 1.2	<.0001^4-150
Liver histology scores⁷:
Piecemeal Necrosis	1 (0-1)	0 (0-1)	.0126^4-151
Intralobular degeneration	1 (1-3)	0 (0-1)	.0001^4-151
Portal inflammation	1 (1-3)	1 (1-1)	.0063^4-151
Fibrosis	3 (3-3)	3 (1-3)	.18^4-151
Knodell index^‡	6.9 ± 3	4.9 ± 2.8	<.0001^4-150

Data were available for 39 patients.

F4-150

Tests of significance were performed with paired Students' t-test for comparison of mean ± SD.

F4-151

Wilcoxon test for comparison of ordered values (median [25 to 75 percentile]). Thirty-three patients were anti-HCV seropositive and 27 had HCV viremia as detected by PCR.

‡

See Appendix 2.

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