Clinical and Hematological Data of 19 Patients With t(16; 21)-AML
| Patient No. . | Age/Sex (yr) . | FAB Subtype . | Other Chromosomal Abnormalities . | WBC . | Blast (%) . | Eos (%) . | Auer Rods . | Survival After Diagnosis (mo) . | |
|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | (109/L) . | PB . | BM . | . | . | . |
| 1* | 11/F | M2† | del(7)(q32) | 14.7 | 30 | 24.8 | 4 | − | 24 |
| 2* | 10/M | M7† | 2.9 | + | 18 | ||||
| 3 | 2/F | M1 | 39.2 | 62 | 56.5 | 0 | − | 38+ | |
| 4* | 41/F | M1 | 44.2 | 78 | 90.1 | 0 | − | 16 | |
| 5 | 22/F | M2 | 12.4 | 52 | 3 | − | 10 | ||
| 6 | 22/F | M2 | 2.4 | 86 | 92 | 0 | 10 | ||
| 7* | 42/F | M2 | 0.8 | 18 | 65.1 | 5 | − | 12 | |
| 8 | 9/F | M4 | t(9; 16), t(2; 18) | 1.9 | 8 | 55 | 0 | − | 26 |
| 9* | 24/F | M5a | del(1)(p13),+del(1)(p13), der(14)t(1; 14)(p11; p11.2) | 18.7 | 83 | 86 | 0 | − | 15 |
| 10 | 14/F | M5b | 19.9 | 85 | 89.4 | 4 | − | 16 | |
| 11 | 6/M | M7 | del(7q) | 102.0 | 0 | − | 16 | ||
| 12* | 11/M | M7 | 11.8 | 4.6 | − | 13 | |||
| 13 | 12/M | M1 | 6.9 | 74.5 | 73.6 | 0 | − | 33 | |
| 14 | 46/M | M1 | t(1; 16)(q12; q13), t(6; 12)(q21; q13) | 120.3 | 91.4 | 91 | 0 | − | 12 |
| 15* | 25/F | M2 | +X/+X, +8 | 4.8 | 42 | 80 | 0 | + | 13 |
| 16 | 42/M | M2 | 1.9 | 70-80 | 2 | − | 13 | ||
| 17 | 23/F | M5a | +1q | 2.3 | 54 | 90 | 0.3 | − | 16 |
| 18 | 39/M | M5b | 103.4 | 2.5 | − | 17 | |||
| 19 | 61/M | M5b | 11.2 | 70 | 20.8 | 2 | − | 6 | |
| Patient No. . | Age/Sex (yr) . | FAB Subtype . | Other Chromosomal Abnormalities . | WBC . | Blast (%) . | Eos (%) . | Auer Rods . | Survival After Diagnosis (mo) . | |
|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | (109/L) . | PB . | BM . | . | . | . |
| 1* | 11/F | M2† | del(7)(q32) | 14.7 | 30 | 24.8 | 4 | − | 24 |
| 2* | 10/M | M7† | 2.9 | + | 18 | ||||
| 3 | 2/F | M1 | 39.2 | 62 | 56.5 | 0 | − | 38+ | |
| 4* | 41/F | M1 | 44.2 | 78 | 90.1 | 0 | − | 16 | |
| 5 | 22/F | M2 | 12.4 | 52 | 3 | − | 10 | ||
| 6 | 22/F | M2 | 2.4 | 86 | 92 | 0 | 10 | ||
| 7* | 42/F | M2 | 0.8 | 18 | 65.1 | 5 | − | 12 | |
| 8 | 9/F | M4 | t(9; 16), t(2; 18) | 1.9 | 8 | 55 | 0 | − | 26 |
| 9* | 24/F | M5a | del(1)(p13),+del(1)(p13), der(14)t(1; 14)(p11; p11.2) | 18.7 | 83 | 86 | 0 | − | 15 |
| 10 | 14/F | M5b | 19.9 | 85 | 89.4 | 4 | − | 16 | |
| 11 | 6/M | M7 | del(7q) | 102.0 | 0 | − | 16 | ||
| 12* | 11/M | M7 | 11.8 | 4.6 | − | 13 | |||
| 13 | 12/M | M1 | 6.9 | 74.5 | 73.6 | 0 | − | 33 | |
| 14 | 46/M | M1 | t(1; 16)(q12; q13), t(6; 12)(q21; q13) | 120.3 | 91.4 | 91 | 0 | − | 12 |
| 15* | 25/F | M2 | +X/+X, +8 | 4.8 | 42 | 80 | 0 | + | 13 |
| 16 | 42/M | M2 | 1.9 | 70-80 | 2 | − | 13 | ||
| 17 | 23/F | M5a | +1q | 2.3 | 54 | 90 | 0.3 | − | 16 |
| 18 | 39/M | M5b | 103.4 | 2.5 | − | 17 | |||
| 19 | 61/M | M5b | 11.2 | 70 | 20.8 | 2 | − | 6 | |
Abbreviations: yr, year; M, male; F, female; Eos, eosinophils; +, alive.
Blanks indicate data not available.
Previously reported patients: patients 1, 2, 4, 12, and 15 same as the patients 4, 5, 1, 3, and 2 in ref. 16, and patients 7 and 9 same as the patients 6 and 7 in ref. 17.
Refractory anemia with excess of blasts in transformation (RAEBt) was precedent.