Table 3. Effect of Low-Mg Diet in β Thal... | American Society of Hematology

Table 3.

Effect of Low-Mg Diet in β Thal Mice

Parameter	Baseline (n = 6)	Day 14 (n = 6)	Day 28 (n = 6)
Hct (%)	32.8 ± 1.5	29.9 ± 1.7^3-150	21.4 ± 0.8^3-150
Hb (g/dL)	10.2 ± 0.4	8.4 ± 0.4^3-150	6.7 ± 0.1^3-150
MCHC (g/dL)	32.1 ± 1.0	33.2 ± 0.6^†	33.3 ± 0.7^†
D₅₀	1.102 ± 0.001	1.104 ± 0.001^3-150	1.107 ± 0.002^3-150
Reticulocytes (%)	28.3 ± 3.2	39.5 ± 4.8^3-150	42.8 ± 7.2^3-150
Corrected reticulocyte count (%)	20.5 ± 2.3	26.1 ± 3.2^3-150	20.3 ± 3.4
Serum Mg (mmol/L)	1.9 ± 0.3	0.6 ± 0.1^3-150	0.3 ± 0.1^3-150
Erythrocyte Mg (mmol/kg Hb)	9.1 ± 0.3	8.7 ± 0.2^†	6.4 ± 0.1^3-150
Cell Na (mmol/kg Hb)	51.1 ± 1.7	54.2 ± 1.7^†	55.0 ± 1.5^3-150
Cell K (mmol/kg Hb)	291 ± 10	242 ± 8.2^3-150	251.1 ± 21^3-150
Cell Na + K (mmol/kg Hb)	342.3 ± 13.7	302 ± 7.9^3-150	306 ± 11.2^3-150
K-Cl cotransport (mmol/L cells⋅h)	11.9 ± 0.9	29.7 ± 7.6^3-150	24.9 ± 6.4^3-150

Parameter	Baseline (n = 6)	Day 14 (n = 6)	Day 28 (n = 6)
Hct (%)	32.8 ± 1.5	29.9 ± 1.7^3-150	21.4 ± 0.8^3-150
Hb (g/dL)	10.2 ± 0.4	8.4 ± 0.4^3-150	6.7 ± 0.1^3-150
MCHC (g/dL)	32.1 ± 1.0	33.2 ± 0.6^†	33.3 ± 0.7^†
D₅₀	1.102 ± 0.001	1.104 ± 0.001^3-150	1.107 ± 0.002^3-150
Reticulocytes (%)	28.3 ± 3.2	39.5 ± 4.8^3-150	42.8 ± 7.2^3-150
Corrected reticulocyte count (%)	20.5 ± 2.3	26.1 ± 3.2^3-150	20.3 ± 3.4
Serum Mg (mmol/L)	1.9 ± 0.3	0.6 ± 0.1^3-150	0.3 ± 0.1^3-150
Erythrocyte Mg (mmol/kg Hb)	9.1 ± 0.3	8.7 ± 0.2^†	6.4 ± 0.1^3-150
Cell Na (mmol/kg Hb)	51.1 ± 1.7	54.2 ± 1.7^†	55.0 ± 1.5^3-150
Cell K (mmol/kg Hb)	291 ± 10	242 ± 8.2^3-150	251.1 ± 21^3-150
Cell Na + K (mmol/kg Hb)	342.3 ± 13.7	302 ± 7.9^3-150	306 ± 11.2^3-150
K-Cl cotransport (mmol/L cells⋅h)	11.9 ± 0.9	29.7 ± 7.6^3-150	24.9 ± 6.4^3-150

Data are presented as the mean ± SD. Corrected reticulocyte count based on baseline 45.2% Hct of C57BL/6 controls (see Table 1).

P < .005, † P < .05: v baseline.