Table 3. p53 Positivity by ICC and... | American Society of Hematology

Table 3.

p53 Positivity by ICC and Corresponding p53 Gene Mutations Detected by cDNA Sequence Analysis

Case No.	p53 Protein (% positive cells)	Exon	Codon	Nucleotide Substitution	AA Substitution
1	72	5	129	T → C	Ala → Val
2	97	4	72^*	G → T	Pro → Arg
		5	143	C → T	Val → Ala
3	64	7	201	A → T	Met → Lys
4	59	5	143	C → T	Val → Ala
		9	301	Del A	Out of frame
		10	314^*	T → C	Ser → Phe
5	97	4	64^*	G → C	Pro → Ala
		4	72^*	G → T	Pro → Arg
		5	143	C → T	Val → Ala
6	55	5	143	C → T	Val → Ala
7	95	5	110	T → C	Arg → Pro
8	89	WT		WT
9	3	5	143	C → T	Val → Ala
		9	286	G → A	Glu → Gly
10	85	WT		WT
11	97	5	129	T → C	Ala → Val
		5	143	C → T	Val → Ala
12	6	5	143	C → T	Val → Ala
13	1	5	143	C → T	Val → Ala
		6	189	G → T	Pro → Ala
		10	328^*	T → C	Thr → Isol
14	1.5	5	143	C → T	Val → Ala
		5	140	G → T	Cys → Gly
15	14	5	143	C → T	Val → Ala
16	19	5	132	A → T	Met → Aspar
		7	209	C → A	Aspar → Hist
17	29	5	132	A → T	Met → Aspar

Case No.	p53 Protein (% positive cells)	Exon	Codon	Nucleotide Substitution	AA Substitution
1	72	5	129	T → C	Ala → Val
2	97	4	72^*	G → T	Pro → Arg
		5	143	C → T	Val → Ala
3	64	7	201	A → T	Met → Lys
4	59	5	143	C → T	Val → Ala
		9	301	Del A	Out of frame
		10	314^*	T → C	Ser → Phe
5	97	4	64^*	G → C	Pro → Ala
		4	72^*	G → T	Pro → Arg
		5	143	C → T	Val → Ala
6	55	5	143	C → T	Val → Ala
7	95	5	110	T → C	Arg → Pro
8	89	WT		WT
9	3	5	143	C → T	Val → Ala
		9	286	G → A	Glu → Gly
10	85	WT		WT
11	97	5	129	T → C	Ala → Val
		5	143	C → T	Val → Ala
12	6	5	143	C → T	Val → Ala
13	1	5	143	C → T	Val → Ala
		6	189	G → T	Pro → Ala
		10	328^*	T → C	Thr → Isol
14	1.5	5	143	C → T	Val → Ala
		5	140	G → T	Cys → Gly
15	14	5	143	C → T	Val → Ala
16	19	5	132	A → T	Met → Aspar
		7	209	C → A	Aspar → Hist
17	29	5	132	A → T	Met → Aspar

Abbreviation: WT, wild-type.

Codons located outside the evolutionary conserved p53 regions.